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    relB antitoxin/DNA-binding transcriptional repressor RelB [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948308, updated on 3-Dec-2024

    Summary

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    Official Symbol
    relB
    Official Full Name
    antitoxin/DNA-binding transcriptional repressor RelB
    Primary source
    ECOCYC:EG10836
    Locus tag
    b1564
    See related
    ASAP:ABE-0005224
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1558; RC
    Summary
    RelB is the antitoxin of the RelE-RelB toxin-antitoxin system . [More information is available at EcoCyc: EG10836].
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    Genomic context

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    Sequence:
    NC_000913.3 (1645633..1645872, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene toxic protein HokD Neighboring gene mRNA interferase toxin RelE Neighboring gene protein YdfV Neighboring gene PF14282 family protein FlxA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evidence that glucose starvation-sensitive mutants are altered in the relB locus. Mosteller RD. J Bacteriol, 1978 Feb. PMID 342488, Free PMC Article
    2. Variations in phenotype of relB mutants of Escherichia coli and the effect of pus and sup mutations. Diderichsen B, et al. Mol Gen Genet, 1980. PMID 6162075
    3. Improved mapping of ksgB and integration of transposons near relB and terC in Escherichia coli. Diderichsen B. J Bacteriol, 1981 Apr. PMID 6260745, Free PMC Article
    4. RelE-mediated dormancy is enhanced at high cell density in Escherichia coli. Tashiro Y, et al. J Bacteriol, 2012 Mar. PMID 22210768, Free PMC Article
    5. Genetics of the relB locus in Escherichia coli. Diderichsen B, et al. J Bacteriol, 1977 Jul. PMID 326765, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, the authors report that the transition to dormant states is mediated by one of the major toxin-antitoxin systems, RelEB, in a cell density-dependent manner in Escherichia coli K-12 MG1655.
      Title: RelE-mediated dormancy is enhanced at high cell density in Escherichia coli.
    2. molecular interactions important for transcriptional control of the relBE model operon were characterized.
      Title: RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables toxin sequestering activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of DNA-templated transcription NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in single-species biofilm formation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of protein-DNA complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of protein-DNA complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    antitoxin/DNA-binding transcriptional repressor RelB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1645633..1645872 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416082.1 antitoxin/DNA-binding transcriptional repressor RelB [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416082.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK11235
      Location:1 → 79
      PRK11235; type II toxin-antitoxin system RelB/DinJ family antitoxin
    Nucleotide Protein
    Heading Accession and Version

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