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    hokD toxic protein HokD [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948616, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hokD
    Official Full Name
    toxic protein HokD
    Primary source
    ECOCYC:EG11130
    Locus tag
    b1562
    See related
    ASAP:ABE-0005219
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1556; relF
    Summary
    hokD regulatory elements are apparently deleted in K-12 and hokD is fused to relBE transcript. [More information is available at EcoGene: EG11130]. Sequence analysis indicates that the hokD gene is a homologue of the hok (host killing) gene which is responsible for mediating plasmid stabilization by post-segregational killing (PSK) in plasmid R1. hok encodes a stable mRNA whose translation is inhibited by a less stable mRNA encoded by sok. [More information is available at EcoCyc: EG11130].
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    Genomic context

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    Sequence:
    NC_000913.3 (1645119..1645274, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YdfU Neighboring gene protein Rem Neighboring gene mRNA interferase toxin RelE Neighboring gene antitoxin/DNA-binding transcriptional repressor RelB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Development of efficient suicide mechanisms for biological containment of bacteria. Knudsen SM, et al. Appl Environ Microbiol, 1991 Jan. PMID 2036024, Free PMC Article
    2. Development and testing of improved suicide functions for biological containment of bacteria. Knudsen S, et al. Appl Environ Microbiol, 1995 Mar. PMID 7793926, Free PMC Article
    3. A family of genes encoding a cell-killing function may be conserved in all gram-negative bacteria. Poulsen LK, et al. Mol Microbiol, 1989 Nov. PMID 2693900
    4. Sequence of the relB transcription unit from Escherichia coli and identification of the relB gene. Bech FW, et al. EMBO J, 1985 Apr. PMID 2990907, Free PMC Article
    5. Analysis of an Escherichia coli mutant strain resistant to the cell-killing function encoded by the gef gene family. Poulsen LK, et al. Mol Microbiol, 1992 Apr. PMID 1602968

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Component Evidence Code Pubs
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    toxic protein HokD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1645119..1645274 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416080.1 toxic protein HokD [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416080.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P0ACG6
      Conserved Domains (1) summary
      pfam01848
      Location:6 → 47
      HOK_GEF; Hok/gef family
    Nucleotide Protein
    Heading Accession and Version

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