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    rna RNase I [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949065, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rna
    Official Full Name
    RNase I
    Primary source
    ECOCYC:EG10856
    Locus tag
    b0611
    See related
    ASAP:ABE-0002107
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0604; rnsA
    Summary
    Ribonuclease I (RNase I) is an endonuclease that cleaves phosphodiester bonds in RNA, yielding nucleoside 3'-phosphates and 3'-phosphooligonucleotides . [More information is available at EcoCyc: EG10856].
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    Genomic context

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    Sequence:
    NC_000913.3 (644197..645003, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein YldA Neighboring gene nucleoside diphosphate kinase regulator Neighboring gene citrate:succinate antiporter Neighboring gene triphosphoribosyl-dephospho-CoA synthase Neighboring gene apo-citrate lyase phosphoribosyl-dephospho-CoA transferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Cloning and sequencing the gene encoding Escherichia coli ribonuclease I: exact physical mapping using the genome library. Meador J 3rd, et al. Gene, 1990 Oct 30. PMID 2253883
    2. Isolation and characterization of ribonuclease I mutants of Escherichia coli. Gesteland RF. J Mol Biol, 1966 Mar. PMID 5331244
    3. The release of ribonuclease into the medium when E. coli cells are converted to spheroplasts. Neu HC, et al. Biochem Biophys Res Commun, 1964. PMID 5319839
    4. E. coli RNase I exhibits a strong Ca2+-dependent inherent double-stranded RNase activity. Grünberg S, et al. Nucleic Acids Res, 2021 May 21. PMID 33885787, Free PMC Article
    5. Physical properties of ribosomal ribonucleic acid isolated from bacteria deficient in ribonuclease I. Cammack KA, et al. Biochem J, 1970 May. PMID 4915439, Free PMC Article

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. E. coli RNase I exhibits a strong Ca2+-dependent inherent double-stranded RNase activity.
      Title: E. coli RNase I exhibits a strong Ca2+-dependent inherent double-stranded RNase activity.
    2. Substantiating prior suggestions that MRE600 lacks RNase I activity, the RNase I-encoding gene, rna, contains a single premature stop codon early in its open-reading frame.
      Title: Genome Sequence and Analysis of Escherichia coli MRE600, a Colicinogenic, Nonmotile Strain that Lacks RNase I and the Type I Methyltransferase, EcoKI.
    3. N-terminus verified by Edman degradation on mature peptide
      Title: Cloning and sequencing the gene encoding Escherichia coli ribonuclease I: exact physical mapping using the genome library.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables Enterobacter ribonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribonuclease T2 activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within RNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    RNase I
    NP_415144.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      644197..645003 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415144.1 RNase I [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415144.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T5ZC59, Q8GL53
      Conserved Domains (1) summary
      PRK10095
      Location:1 → 268
      PRK10095; ribonuclease I; Provisional
    Nucleotide Protein
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