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    thiB thiamine ABC transporter periplasmic binding protein [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946306, updated on 17-Dec-2024

    Summary

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    Official Symbol
    thiB
    Official Full Name
    thiamine ABC transporter periplasmic binding protein
    Primary source
    ECOCYC:EG11574
    Locus tag
    b0068
    See related
    ASAP:ABE-0000249
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0069; sfuA; tbpA; yabL
    Summary
    thiBPQ operon expression is controlled by a thiamine pyrophosphate (TPP) responsive riboswitch in the 128 nt 5' UTR. [More information is available at EcoGene: EG11574]. The Escherichia coli SufA/TbpA protein has been purified and characterized as a 34.2 kDa monomer. [More information is available at EcoCyc: EG11574].
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    Genomic context

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    Sequence:
    NC_000913.3 (74497..75480, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DedA family protein YabI Neighboring gene thiamine ABC transporter ATP binding subunit Neighboring gene thiamine ABC transporter membrane subunit Neighboring gene ncRNA Neighboring gene DNA-binding transcriptional dual regulator SgrR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A rapid assay procedure for thiamine-binding protein of Escherichia coli. Nishimune T, et al. Anal Biochem, 1973 May. PMID 4575944
    2. [Proteins specifically binding thiamine and their biological role]. Rybina AA, et al. Ukr Biokhim Zh (1978), 1980 Sep-Oct. PMID 6789521
    3. Structural similarities between thiamin-binding protein and thiaminase-I suggest a common ancestor. Soriano EV, et al. Biochemistry, 2008 Feb 5. PMID 18177053, Free PMC Article
    4. Thiamin-binding proteins. Itokawa Y, et al. Ann N Y Acad Sci, 1982. PMID 7044227
    5. Thiamine-binding protein of Escherichia coli. Iwashima A, et al. J Bacteriol, 1971 Dec. PMID 4945201, Free PMC Article

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables thiamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thiamine pyrophosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine pyrophosphate binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in thiamine transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in thiamine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within thiamine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thiamine transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of ATP-binding cassette (ABC) transporter complex, substrate-binding subunit-containing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in outer membrane-bounded periplasmic space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in outer membrane-bounded periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    thiamine ABC transporter periplasmic binding protein
    NP_414610.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      74497..75480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414610.1 thiamine ABC transporter periplasmic binding protein [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414610.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EBT5
      Conserved Domains (1) summary
      PRK11205
      Location:13 → 327
      tbpA; thiamine transporter substrate binding subunit; Provisional
    Nucleotide Protein
    Heading Accession and Version

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