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    tmk Tmk [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945663, updated on 17-Dec-2024

    Summary

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    Official Symbol
    tmk
    Official Full Name
    Tmk
    Primary source
    ECOCYC:EG12302
    Locus tag
    b1098
    See related
    ASAP:ABE-0003714
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1084; ycfG
    Summary
    Essential gene. [More information is available at EcoGene: EG12302]. The enzyme is responsible for specifically catalyzing the conversion of dTMP to dTDP. dTMP kinase is the last unique enzyme in the pathway leading to dTTP. [More information is available at EcoCyc: EG12302].
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    Genomic context

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    Sequence:
    NC_000913.3 (1155124..1155765)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-oxoacyl-[acyl carrier protein] synthase 2 Neighboring gene aminodeoxychorismate lyase Neighboring gene endolytic murein transglycosylase Neighboring gene DNA polymerase III subunit delta' Neighboring gene putative metal-dependent hydrolase YcfH Neighboring gene glucose-specific PTS enzyme IIBC component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The highly similar TMP kinases of Yersinia pestis and Escherichia coli differ markedly in their AZTMP phosphorylating activity. Chenal-Francisque V, et al. Eur J Biochem, 1999 Oct 1. PMID 10491164
    2. Substitution of an alanine residue for glycine 146 in TMP kinase from Escherichia coli is responsible for bacterial hypersensitivity to bromodeoxyuridine. Tourneux L, et al. J Bacteriol, 1998 Aug. PMID 9696781, Free PMC Article
    3. Isolation and characterization of an Escherichia coli mutant deficient in dTMP kinase activity. Daws TD, et al. J Bacteriol, 1984 Feb. PMID 6319360, Free PMC Article
    4. Purification and characterization of Thymidine 5-monophosphate kinase from Escherichia coli B. Nelson DJ, et al. J Biol Chem, 1969 Oct 10. PMID 4899016
    5. Genetic mapping in Escherichia coli of tmk, the locus for dTMP kinase. Binkley JP, et al. J Bacteriol, 1986 Dec. PMID 3023302, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidylate kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thymidylate kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thymidylate kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in dTDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dTDP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dTDP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTDP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dTTP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within dTTP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in dTTP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in dTTP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dUDP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within nucleobase-containing small molecule interconversion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nucleoside monophosphate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tmk
    NP_415616.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1155124..1155765
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415616.1 Tmk [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415616.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1NCY5, A0A376FNT3, A0A6C9QGJ2, A0AAN3HAE9
      Conserved Domains (1) summary
      PRK00698
      Location:1 → 209
      tmk; thymidylate kinase; Validated
    Nucleotide Protein
    Heading Accession and Version

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