U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    tynA copper-containing amine oxidase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945939, updated on 3-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    tynA
    Official Full Name
    copper-containing amine oxidase
    Primary source
    ECOCYC:EG13139
    Locus tag
    b1386
    See related
    ASAP:ABE-0004639
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1383; feaA; maoA
    Summary
    Topaquinone (TPQ) is 2,4,5-trihydroxyphenylalanine quinone, and is derived from a tyrosyl residue in the active site, in a copper-dependent oxidation reaction. [More information is available at EcoGene: EG13140].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (1449076..1451349, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding transcriptional activator FeaR Neighboring gene phenylacetaldehyde dehydrogenase Neighboring gene fused 3-oxo-5,6-dehydrosuberyl-CoA semialdehyde dehydrogenase and oxepin-CoA hydrolase Neighboring gene phenylacetyl-CoA 1,2-epoxidase, monooxygenase subunit

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Conserved tyrosine-369 in the active site of Escherichia coli copper amine oxidase is not essential. Murray JM, et al. Biochemistry, 2001 Oct 30. PMID 11669617
    2. Copper amine oxidase: a novel use for a tyrosine. Fontecave M, et al. Structure, 1995 Nov 15. PMID 8591022
    3. Intermediates in the catalytic cycle of copper-quinoprotein amine oxidase from Escherichia coli. Steinebach V, et al. J Biol Chem, 1996 Mar 8. PMID 8621418
    4. Crystallization and preliminary X-ray analysis of copper amine oxidase from Escherichia coli K-12. Roh JH, et al. J Mol Biol, 1994 May 13. PMID 8176752
    5. Catalytic mechanism of the quinoenzyme amine oxidase from Escherichia coli: exploring the reductive half-reaction. Wilmot CM, et al. Biochemistry, 1997 Feb 18. PMID 9048544

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Only strains that produce TynA and FeaB converting norepinephrine to 3,4-dihydroxymandelic acid xhibited chemotaxis toward norepinephrine and 3,4-dihydroxymandelic acid is sensed by the serine chemoreceptor Tsr.
      Title: Chemotaxis of Escherichia coli to norepinephrine (NE) requires conversion of NE to 3,4-dihydroxymandelic acid.
    2. Using genetic, biochemical and computational approaches, authors show that the FeaR binding site is a TGNCA-N8-AAA motif that occurs in 2 copies in the tynA and feaB promoters.
      Title: Finely tuned regulation of the aromatic amine degradation pathway in Escherichia coli.
    3. proposed that Y381, together with another residue Y387, may be considered of critical importance for the substrate selectivity of copper amine oxidase through stacking or hydrophobic interactions with substrate
      Title: Tyrosine 381 in E. coli copper amine oxidase influences substrate specificity.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: 2-phenylethylamine catabolism by Escherichia coli K-12: gene organization and expression.
    5. X-ray crystal structure of the copper-containing quinoprotein amine oxidase determined in complex with the antidepressant drug tranylcypromine.
      Title: Medical implications from the crystal structure of a copper-containing amine oxidase complexed with the antidepressant drug tranylcypromine.
    Submit: New GeneRIF Correction

    Pathways from PubChem

    Go to the top of the page

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables aliphatic amine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables primary methylamine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables primary methylamine oxidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables primary methylamine oxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables quinone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables quinone binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-phenylalanine catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in amine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in amine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within phenylethylamine catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within phenylethylamine catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    copper-containing amine oxidase
    NP_415904.3

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1449076..1451349 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415904.3 copper-containing amine oxidase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415904.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376WYY1, A0A8T5YGT1
      Conserved Domains (1) summary
      PRK14696
      Location:37 → 757
      tynA; primary-amine oxidase
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.