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    ppiD periplasmic folding chaperone [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946056, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ppiD
    Official Full Name
    periplasmic folding chaperone
    Primary source
    ECOCYC:G6242
    Locus tag
    b0441
    See related
    ASAP:ABE-0001531
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0435; ybaU
    Summary
    PpiD is a periplasmic enyzyme with N-terminal membrane anchor. [More information is available at EcoGene: EG13249]. The ppiD gene encodes a peptidyl-prolyl isomerase (PPIase) . [More information is available at EcoCyc: G6242].
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    Genomic context

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    Sequence:
    NC_000913.3 (461915..463786)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene Lon protease Neighboring gene DNA-binding protein HU-beta Neighboring gene helix-hairpin-helix 3 family protein Neighboring gene long-chain acyl-CoA thioesterase FadM

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Involvement of PpiD in Sec-dependent protein translocation. Fürst M, et al. Biochim Biophys Acta Mol Cell Res, 2018 Feb. PMID 29097228
    2. The prolyl isomerase domain of PpiD from Escherichia coli shows a parvulin fold but is devoid of catalytic activity. Weininger U, et al. Protein Sci, 2010 Jan. PMID 19866485, Free PMC Article
    3. The Central Spike Complex of Bacteriophage T4 Contacts PpiD in the Periplasm of Escherichia coli. Wenzel S, et al. Viruses, 2020 Oct 6. PMID 33036312, Free PMC Article
    4. A new heat-shock gene, ppiD, encodes a peptidyl-prolyl isomerase required for folding of outer membrane proteins in Escherichia coli. Dartigalongue C, et al. EMBO J, 1998 Jul 15. PMID 9670013, Free PMC Article
    5. PpiD is a player in the network of periplasmic chaperones in Escherichia coli. Matern Y, et al. BMC Microbiol, 2010 Sep 29. PMID 20920237, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The Central Spike Complex of Bacteriophage T4 Contacts PpiD in the Periplasm of Escherichia coli.
      Title: The Central Spike Complex of Bacteriophage T4 Contacts PpiD in the Periplasm of Escherichia coli.
    2. The results of this study indicate that the PpiD/YfgM chaperone complex is a primary interaction partner of the SecYEG translocon.
      Title: Noncompetitive binding of PpiD and YidC to the SecYEG translocon expands the global view on the SecYEG interactome in Escherichia coli.
    3. PpiD contributes to the efficient detachment of newly secreted OmpA from the inner membrane and in doing so, seems to cooperate in a hierarchical manner with other periplasmic chaperones such as SurA, DegP, and Skp.
      Title: Involvement of PpiD in Sec-dependent protein translocation.
    4. PpiD functions as a chaperone and contributes to the network of periplasmic chaperone activities
      Title: PpiD is a player in the network of periplasmic chaperones in Escherichia coli.
    5. although PpiD and SurA have partially overlapping substrate specificities, they fulfil different functions in the cell
      Title: The periplasmic peptidyl prolyl cis-trans isomerases PpiD and SurA have partially overlapping substrate specificities.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables peptidyl-prolyl cis-trans isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    periplasmic folding chaperone

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      461915..463786
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414975.1 periplasmic folding chaperone [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414975.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TPJ0, A0A418GQ35, A0A6L7CDN2, A0A895P5N1
      Conserved Domains (1) summary
      PRK10788
      Location:1 → 619
      PRK10788; periplasmic folding chaperone; Provisional
    Nucleotide Protein
    Heading Accession and Version

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