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    nadD nicotinate-nucleotide adenylyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945248, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nadD
    Official Full Name
    nicotinate-nucleotide adenylyltransferase
    Primary source
    ECOCYC:G6350
    Locus tag
    b0639
    See related
    ASAP:ABE-0002187
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0632; fusB; ybeN
    Summary
    Nicotinate-mononucleotide adenylyltransferase is an essential enzyme involved in both de novo biosynthesis and salvage of NAD+ and NADPH. [More information is available at EcoCyc: G6350].
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    Genomic context

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    Sequence:
    NC_000913.3 (669931..670572, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene ribosomal silencing factor RsfS Neighboring gene putative adenosylcobalamin phosphatase/alpha-ribazole phosphatase Neighboring gene DNA polymerase III subunit delta Neighboring gene lipopolysaccharide assembly protein LptE Neighboring gene leucine--tRNA ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis. Wang X, et al. Appl Environ Microbiol, 2017 Jul 1. PMID 28455340, Free PMC Article
    2. Targeting NAD biosynthesis in bacterial pathogens: Structure-based development of inhibitors of nicotinate mononucleotide adenylyltransferase NadD. Sorci L, et al. Chem Biol, 2009 Aug 28. PMID 19716475, Free PMC Article
    3. Analysis of Escherichia coli nicotinate mononucleotide adenylyltransferase mutants in vivo and in vitro. Stancek M, et al. BMC Biochem, 2005 Sep 9. PMID 16153292, Free PMC Article
    4. fusB is an allele of nadD, encoding nicotinate mononucleotide adenylyltransferase in Escherichia coli. Stancek M, et al. Microbiology (Reading), 2003 Sep. PMID 12949168
    5. Crystal structures of E. coli nicotinate mononucleotide adenylyltransferase and its complex with deamido-NAD. Zhang H, et al. Structure, 2002 Jan. PMID 11796112

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of Y84V/Y118D and A86W/Y118N of NadD resulted in a high preference for nicotinamide mononucleotide.
      Title: Engineering Escherichia coli Nicotinic Acid Mononucleotide Adenylyltransferase for Fully Active Amidated NAD Biosynthesis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nicotinamide-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate-nucleotide adenylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinate-nucleotide adenylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nicotinate-nucleotide adenylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within 'de novo' NAD biosynthetic process from aspartate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in NAD biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in NAD biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within NAD salvage IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in pyridine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    nicotinate-nucleotide adenylyltransferase
    NP_415172.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      669931..670572 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415172.1 nicotinate-nucleotide adenylyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415172.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1WYY9
      Conserved Domains (1) summary
      PRK00071
      Location:1 → 213
      nadD; nicotinate-nucleotide adenylyltransferase
    Nucleotide Protein
    Heading Accession and Version

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