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    nagK N-acetyl-D-glucosamine kinase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945664, updated on 3-Dec-2024

    Summary

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    Official Symbol
    nagK
    Official Full Name
    N-acetyl-D-glucosamine kinase
    Primary source
    ECOCYC:G6576
    Locus tag
    b1119
    See related
    ASAP:ABE-0003778
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1105; ycfX
    Summary
    nagK is not an essential gene. [More information is available at EcoGene: EG13442]. N-acetyl-D-glucosamine (GlcNAc) is released in the cytoplasm during murein recycling. [More information is available at EcoCyc: G6576].
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    Genomic context

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    Sequence:
    NC_000913.3 (1178593..1179504)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene lipoprotein release complex - inner membrane subunit Neighboring gene lipoprotein release complex - ATP binding subunit Neighboring gene lipoprotein release complex - inner membrane subunit Neighboring gene CobB-S;protein-lysine deacetylase/desuccinylase/lipoamidase Neighboring gene putative inner membrane protein YcfZ Neighboring gene putative inner membrane protein YmfA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The N-acetyl-D-glucosamine kinase of Escherichia coli and its role in murein recycling. Uehara T, et al. J Bacteriol, 2004 Nov. PMID 15489439, Free PMC Article
    2. Identifying latent enzyme activities: substrate ambiguity within modern bacterial sugar kinases. Miller BG, et al. Biochemistry, 2004 Jun 1. PMID 15157072
    3. An alternative route for recycling of N-acetylglucosamine from peptidoglycan involves the N-acetylglucosamine phosphotransferase system in Escherichia coli. Plumbridge J. J Bacteriol, 2009 Sep. PMID 19617367, Free PMC Article
    4. How bacteria consume their own exoskeletons (turnover and recycling of cell wall peptidoglycan). Park JT, et al. Microbiol Mol Biol Rev, 2008 Jun. PMID 18535144, Free PMC Article
    5. Interaction network containing conserved and essential protein complexes in Escherichia coli. Butland G, et al. Nature, 2005 Feb 3. PMID 15690043

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables N-acetylglucosamine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables N-acetylglucosamine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables N-acetylglucosamine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in N-acetylglucosamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in carbohydrate phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within peptidoglycan turnover EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in peptidoglycan turnover IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acetyl-D-glucosamine kinase
    NP_415637.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1178593..1179504
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415637.1 N-acetyl-D-glucosamine kinase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415637.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376X2V2, A0A8T6PSL4
      Conserved Domains (1) summary
      PRK13310
      Location:1 → 303
      PRK13310; N-acetyl-D-glucosamine kinase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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