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    ompW outer membrane protein W [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945128, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ompW
    Official Full Name
    outer membrane protein W
    Primary source
    ECOCYC:EG11124
    Locus tag
    b1256
    See related
    ASAP:ABE-0004210
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1250; yciD
    Summary
    OmpW is localized to the cell poles. [More information is available at EcoGene: EG11124]. OmpW is a receptor for Colicin S4 . [More information is available at EcoCyc: EG11124].
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    Genomic context

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    Sequence:
    NC_000913.3 (1314020..1314658)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene inner membrane protein Neighboring gene putative inner membrane protein Neighboring gene DUF892 domain-containing protein YciE Neighboring gene DUF892 domain-containing protein YciF

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel. Hong H, et al. J Biol Chem, 2006 Mar 17. PMID 16414958
    2. Expression, crystallization and preliminary X-ray crystallographic studies of the outer membrane protein OmpW from Escherichia coli. Albrecht R, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Apr 1. PMID 16582500, Free PMC Article
    3. Outer membrane protein OmpW of Escherichia coli is required for resistance to phagocytosis. Wu XB, et al. Res Microbiol, 2013 Oct. PMID 23811183
    4. Contribution of the outer membrane protein OmpW in Escherichia coli to complement resistance from binding to factor H. Li W, et al. Microb Pathog, 2016 Sep. PMID 27364548
    5. Downregulation of Tsx and OmpW and upregulation of OmpX are required for iron homeostasis in Escherichia coli. Lin XM, et al. J Proteome Res, 2008 Mar. PMID 18220334

    See all (31) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Small multidrug resistance protein EmrE phenotypically associates with OmpW, DcrB and YggM for osmotic stress protection by betaine in Escherichia coli.
      Title: Small multidrug resistance protein EmrE phenotypically associates with OmpW, DcrB and YggM for osmotic stress protection by betaine in Escherichia coli.
    2. Moreover, the binding of Escherichia coli OmpW to human factor H, a major inhibitor of alternative complement pathway, was found, indicating that OmpW recruitment of factor H is a mechanism for bacterial evasion of complement attack.
      Title: Contribution of the outer membrane protein OmpW in Escherichia coli to complement resistance from binding to factor H.
    3. Also, DeltahnsDeltastpA double mutants simultaneously lacking H-NS and its paralog StpA showed more severe reductions in ompW expression at 37 degrees C, resulting in the complete loss of OmpW.
      Title: Expression of the Escherichia coli ompW colicin S4 receptor gene is regulated by temperature and modulated by the H-NS and StpA nucleoid-associated proteins.
    4. These results demonstrated that upregulation of OmpW correlated with increased bacterial survival during phagocytosis.
      Title: Outer membrane protein OmpW of Escherichia coli is required for resistance to phagocytosis.
    5. N-terminus verified by Edman degradation on mature peptide
      Title: Extraction of membrane proteins by differential solubilization for separation using two-dimensional gel electrophoresis.
    6. OmpW forms an eight-stranded beta-barrel with a hydrophobic channel
      Title: The outer membrane protein OmpW forms an eight-stranded beta-barrel with a hydrophobic channel.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell outer membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell outer membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cell outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in outer membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    outer membrane protein W

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1314020..1314658
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415772.1 outer membrane protein W [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415772.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A376JYP2
      Conserved Domains (1) summary
      PRK10959
      Location:1 → 212
      PRK10959; outer membrane protein W; Provisional
    Nucleotide Protein
    Heading Accession and Version

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