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    lsrR DNA-binding transcriptional repressor LsrR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946070, updated on 17-Dec-2024

    Summary

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    Official Symbol
    lsrR
    Official Full Name
    DNA-binding transcriptional repressor LsrR
    Primary source
    ECOCYC:G6799
    Locus tag
    b1512
    See related
    ASAP:ABE-0005045
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1505; ydeW
    Summary
    LsrR is also involved in a DHAP repression of the lsr operon. [More information is available at EcoGene: EG13805]. Using particular analysis and high-throughput analysis (microarrays), it was established that LsrR regulates expression of many genes involved in several processes, such as autoinducer 2 uptake and processing , biofilm architecture , host invasion, stress responses, and foreign DNA, among others . [More information is available at EcoCyc: G6799].
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    Genomic context

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    Sequence:
    NC_000913.3 (1600288..1601241, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene autoinducer-2 kinase Neighboring gene Autoinducer-2 ABC transporter ATP binding subunit Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrC Neighboring gene Autoinducer-2 ABC transporter membrane subunit LsrD

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural basis for phosphorylated autoinducer-2 modulation of the oligomerization state of the global transcription regulator LsrR from Escherichia coli. Wu M, et al. J Biol Chem, 2013 May 31. PMID 23589368, Free PMC Article
    2. Quorum sensing in bacteria: the LuxR-LuxI family of cell density-responsive transcriptional regulators. Fuqua WC, et al. J Bacteriol, 1994 Jan. PMID 8288518, Free PMC Article
    3. Escherichia coli autoinducer-2 uptake network does not display hysteretic behavior but AI-2 synthesis rate controls transient bifurcation. Gonzalez Barrios AF, et al. Biosystems, 2010 Jan. PMID 19695305
    4. LsrR-binding site recognition and regulatory characteristics in Escherichia coli AI-2 quorum sensing. Xue T, et al. Cell Res, 2009 Nov. PMID 19636340
    5. AI-3 synthesis is not dependent on luxS in Escherichia coli. Walters M, et al. J Bacteriol, 2006 Aug. PMID 16885435, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables carbohydrate binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription initiation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to heat IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional repressor LsrR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1600288..1601241 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416029.1 DNA-binding transcriptional repressor LsrR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416029.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7F7W4
      Conserved Domains (1) summary
      PRK15418
      Location:2 → 317
      PRK15418; transcriptional regulator LsrR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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