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    dgcN diguanylate cyclase DgcN [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947091, updated on 17-Dec-2024

    Summary

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    Official Symbol
    dgcN
    Official Full Name
    diguanylate cyclase DgcN
    Primary source
    ECOCYC:EG12880
    Locus tag
    b2604
    See related
    ASAP:ABE-0008570
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2601; yfiN
    Summary
    YfiN has a C-terminal putative diguanylate cyclase GGDEF domain. [More information is available at EcoGene: EG12880]. YfiN is an inner membrane protein with two predicted transmembrane domains. [More information is available at EcoCyc: EG12880].
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    Genomic context

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    Sequence:
    NC_000913.3 (2742383..2743609)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-deoxy-7-phosphoheptulonate synthase, Tyr-sensitive Neighboring gene DUF2799 domain-containing lipoprotein YfiL Neighboring gene DUF4154 domain-containing protein YfiR Neighboring gene lipoprotein YfiB Neighboring gene 50S ribosomal subunit protein L19

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Diguanylate Cyclase Acts as a Cell Division Inhibitor in a Two-Step Response to Reductive and Envelope Stresses. Kim HK, et al. mBio, 2016 Aug 9. PMID 27507823, Free PMC Article
    2. GGDEF proteins YeaI, YedQ, and YfiN reduce early biofilm formation and swimming motility in Escherichia coli. Sanchez-Torres V, et al. Appl Microbiol Biotechnol, 2011 Apr. PMID 21181144, Free PMC Article
    3. The nucleotide sequence of an Escherichia coli operon containing genes for the tRNA(m1G)methyltransferase, the ribosomal proteins S16 and L19 and a 21-K polypeptide. Byström AS, et al. EMBO J, 1983. PMID 6357787, Free PMC Article
    4. A comprehensive genetic characterization of bacterial motility. Girgis HS, et al. PLoS Genet, 2007 Sep. PMID 17941710, Free PMC Article
    5. Gene expression patterns and differential input into curli fimbriae regulation of all GGDEF/EAL domain proteins in Escherichia coli. Sommerfeldt N, et al. Microbiology (Reading), 2009 Apr. PMID 19332833

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. YfiN localizes to the Z ring by interacting with early division proteins and stalls cell division by preventing the initiation of septal peptidoglycan synthesis.
      Title: A Diguanylate Cyclase Acts as a Cell Division Inhibitor in a Two-Step Response to Reductive and Envelope Stresses.
    2. YeaI, YedQ, and YfiN are active diguanylate cyclases that reduce motility, eDNA, and early biofilm formation.
      Title: GGDEF proteins YeaI, YedQ, and YfiN reduce early biofilm formation and swimming motility in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables diguanylate cyclase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables diguanylate cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables diguanylate cyclase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables diguanylate cyclase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion involved in single-species biofilm formation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cellular response to cell envelope stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of bacterial-type flagellum-dependent cell motility IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of bacterial-type flagellum-dependent cell motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diguanylate cyclase DgcN
    NP_417095.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2742383..2743609
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417095.1 diguanylate cyclase DgcN [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417095.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A836NB78, A0AAN3V5F4, A7ZQ44, E8PY57, W8TBI8
      Conserved Domains (1) summary
      PRK09966
      Location:2 → 408
      PRK09966; diguanylate cyclase DgcN
    Nucleotide Protein
    Heading Accession and Version

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