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    rlmM 23S rRNA 2'-O-ribose C2498 methyltransferase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947283, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rlmM
    Official Full Name
    23S rRNA 2'-O-ribose C2498 methyltransferase
    Primary source
    ECOCYC:EG11794
    Locus tag
    b2806
    See related
    ASAP:ABE-0009197
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2801; ygdE
    Summary
    By sequence similarity, YgdE is predicted to be an RNA 2'-O-ribose methyltranserase. [More information is available at EcoCyc: EG11794].
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    Genomic context

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    Sequence:
    NC_000913.3 (2940143..2941243, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene L-fucose mutarotase Neighboring gene DNA-binding transcriptional activator FucR Neighboring gene DUF423 domain-containing inner membrane protein YgdD Neighboring gene DNA-binding transcriptional dual regulator GcvA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Purification, crystallization and preliminary crystallographic analysis of the 23S rRNA methyltransferase RlmM (Cm2498) from Escherichia coli. Guo HY, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2013 Jun. PMID 23722841, Free PMC Article
    2. Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA. Punekar AS, et al. Nucleic Acids Res, 2012 Nov 1. PMID 22923526, Free PMC Article
    3. Prediction of a novel RNA 2'-O-ribose methyltransferase subfamily encoded by the Escherichia coli YgdE open reading frame and its orthologs. Bujnicki JM, et al. Acta Microbiol Pol, 2000. PMID 11293658
    4. YgdE is the 2'-O-ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA. Purta E, et al. Mol Microbiol, 2009 Jun. PMID 19400805
    5. Molecular phylogenetics of the RrmJ/fibrillarin superfamily of ribose 2'-O-methyltransferases. Feder M, et al. Gene, 2003 Jan 2. PMID 12527203

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Purification and crystallization of RlmM from Escherichia coli is described.
      Title: Purification, crystallization and preliminary crystallographic analysis of the 23S rRNA methyltransferase RlmM (Cm2498) from Escherichia coli.
    2. Authors have solved the crystal structure of E. coli RlmM and its complex with AdoMet and demonstrated RlmM activity on in vitro-transcribed rRNA.
      Title: Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA.
    3. YgdE is the 2'-O-methyltransferase responsible for modifying 23S rRNA nucleotide C2498, and that modification occurs before assembly of the 50S ribosomal subunit.
      Title: YgdE is the 2'-O-ribose methyltransferase RlmM specific for nucleotide C2498 in bacterial 23S rRNA.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables S-adenosylmethionine-dependent methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA (cytosine-2'-O-)-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in rRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    23S rRNA 2'-O-ribose C2498 methyltransferase
    NP_417286.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2940143..2941243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417286.1 23S rRNA 2'-O-ribose C2498 methyltransferase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417286.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2X1MSQ4
      Conserved Domains (1) summary
      PRK11760
      Location:1 → 357
      PRK11760; putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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