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    yihS sulfoquinovose isomerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948374, updated on 17-Dec-2024

    Summary

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    Official Symbol
    yihS
    Official Full Name
    sulfoquinovose isomerase
    Primary source
    ECOCYC:EG11845
    Locus tag
    b3880
    See related
    ASAP:ABE-0012673
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3873; squS
    Summary
    YihS is a weak D-mannose isomerase and a role for YihQRS in mannan or mannuronan catabolism has been suggested (Itoh, 2008). [More information is available at EcoGene: EG11845]. YihS has mannose isomerase activity in vitro. [More information is available at EcoCyc: EG11845].
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    Genomic context

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    Sequence:
    NC_000913.3 (4070515..4071756, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene sulfoquinovosidase Neighboring gene putative sulfoquinovose mutarotase YihR Neighboring gene 6-deoxy-6-sulfofructose-1-phosphate aldolase Neighboring gene 3-sulfolactaldehyde reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Some properties of D-mannose isomerase from Escherichia coli K12. Stevens FJ, et al. J Gen Microbiol, 1981 May. PMID 7033464
    2. Growth on D-lyxose of a mutant strain of Escherichia coli K12 using a novel isomerase and enzymes related to D-xylase metabolism. Stevens FJ, et al. J Gen Microbiol, 1976 Dec. PMID 796410
    3. Crystal structure of YihS in complex with D-mannose: structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase. Itoh T, et al. J Mol Biol, 2008 Apr 11. PMID 18328504
    4. Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle. Denger K, et al. Nature, 2014 Mar 6. PMID 24463506
    5. Salmonella produces an O-antigen capsule regulated by AgfD and important for environmental persistence. Gibson DL, et al. J Bacteriol, 2006 Nov. PMID 17079680, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Data show that yihS were found to show no AGE activity but showed cofactor-independent aldose-ketose isomerase activity involved in the interconversion of monosaccharides, mannose, fructose, and glucose, or lyxose and xylulose.
      Title: Crystal structure of YihS in complex with D-mannose: structural annotation of Escherichia coli and Salmonella enterica yihS-encoded proteins to an aldose-ketose isomerase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mannose isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfoquinovose isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfoquinovose isomerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfoquinovose isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in 6-sulfoquinovose(1-) catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within 6-sulfoquinovose(1-) catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within 6-sulfoquinovose(1-) catabolic process to glycerone phosphate and 3-sulfolactaldehyde IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in carbohydrate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein hexamerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    sulfoquinovose isomerase
    NP_418316.4

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4070515..4071756 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418316.4 sulfoquinovose isomerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418316.4

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1X3J9M4, A0AAN3M7U5
      Conserved Domains (1) summary
      pfam07221
      Location:32 → 387
      GlcNAc_2-epim; N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase)
    Nucleotide Protein
    Heading Accession and Version

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