U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    ettA energy-dependent translational throttle protein EttA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948909, updated on 17-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    ettA
    Official Full Name
    energy-dependent translational throttle protein EttA
    Primary source
    ECOCYC:EG12343
    Locus tag
    b4391
    See related
    ASAP:ABE-0014400
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4383; yjjK
    Summary
    YjjK is an uncharacterized member of the ABC superfamily of transporters . [More information is available at EcoCyc: EG12343].
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Sequence:
    NC_000913.3 (4628855..4630522, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA recombination protein Neighboring gene DNA-binding transcriptional repressor/NMN adenylyltransferase NadR Neighboring gene soluble lytic murein transglycosylase Neighboring gene DNA-binding transcriptional repressor TrpR

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Global regulation via modulation of ribosome pausing by the ABC-F protein EttA. Ousalem F, et al. Nat Commun, 2024 Jul 26. PMID 39060293, Free PMC Article
    2. The ABC-F protein EttA gates ribosome entry into the translation elongation cycle. Boël G, et al. Nat Struct Mol Biol, 2014 Feb. PMID 24389466, Free PMC Article
    3. EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics. Chen B, et al. Nat Struct Mol Biol, 2014 Feb. PMID 24389465, Free PMC Article
    4. Murein-metabolizing enzymes from Escherichia coli: sequence analysis and controlled overexpression of the slt gene, which encodes the soluble lytic transglycosylase. Engel H, et al. J Bacteriol, 1991 Nov. PMID 1938883, Free PMC Article
    5. Enrichment of low abundance proteins of Escherichia coli by hydroxyapatite chromatography. Fountoulakis M, et al. Electrophoresis, 1999 Aug. PMID 10493123

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Global regulation via modulation of ribosome pausing by the ABC-F protein EttA.
      Title: Global regulation via modulation of ribosome pausing by the ABC-F protein EttA.
    2. EttA (also known as YjjK) is involved in regulating protein synthesis in energy-depleted cells, which have a low ATP/ADP ratio.
      Title: The ABC-F protein EttA gates ribosome entry into the translation elongation cycle.
    3. The ATP-bound form of EttA binds to the ribosomal tRNA-exit site, where it forms bridging interactions between the ribosomal L1 stalk and the tRNA bound in the peptidyl-tRNA-binding site.
      Title: EttA regulates translation by binding the ribosomal E site and restricting ribosome-tRNA dynamics.
    4. N-terminus verified by Edman degradation on mature peptide
      Title: Comparing the predicted and observed properties of proteins encoded in the genome of Escherichia coli K-12.
    Submit: New GeneRIF Correction

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ATP hydrolysis activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H2AZ histone chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent H3-H4 histone complex chaperone activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA clamp loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables chromatin extrusion motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cohesin loader activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribosome binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables tRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin looping IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromatin remodeling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of translational elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of translational elongation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    energy-dependent translational throttle protein EttA

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4628855..4630522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418808.1 energy-dependent translational throttle protein EttA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418808.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A829KXG2, A0AAN3MAW1
      Conserved Domains (1) summary
      PRK11819
      Location:1 → 555
      PRK11819; putative ABC transporter ATP-binding protein; Reviewed
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.