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    appY DNA-binding transcriptional activator AppY [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948797, updated on 17-Dec-2024

    Summary

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    Official Symbol
    appY
    Official Full Name
    DNA-binding transcriptional activator AppY
    Primary source
    ECOCYC:EG10050
    Locus tag
    b0564
    See related
    ASAP:ABE-0001929
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0556
    Summary
    appY expression is induced by PO4 starvation and stationary phase. [More information is available at EcoGene: EG10050]. The AppY, "acid phosphatase," transcriptional regulator induces the expression of energy metabolism genes under anaerobiosis, stationary phase, and phosphate starvation. [More information is available at EcoCyc: EG10050].
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    Genomic context

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    Sequence:
    NC_000913.3 (583681..584430)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene protein TfaX Neighboring gene omptin family outer membrane protease OmpT Neighboring gene DNA-binding transcriptional activator EnvY

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation, characterization, and nucleotide sequence of appY, a regulatory gene for growth-phase-dependent gene expression in Escherichia coli. Atlung T, et al. J Bacteriol, 1989 Mar. PMID 2537825, Free PMC Article
    2. Gains and unexpected lessons from genome-scale promoter mapping. Shavkunov KS, et al. Nucleic Acids Res, 2009 Aug. PMID 19528070, Free PMC Article
    3. Complete nucleotide sequence and deduced amino acid sequence of the M5 polypeptide gene of Escherichia coli. Kemp EH, et al. Nucleic Acids Res, 1987 May 11. PMID 3295784, Free PMC Article
    4. Location of the ompT gene relative to that of appY on the physical map of the Escherichia coli chromosome. Holmes Z, et al. Mol Gen Genet, 1994 Feb. PMID 8107684
    5. The histone-like protein H-NS acts as a transcriptional repressor for expression of the anaerobic and growth phase activator AppY of Escherichia coli. Atlung T, et al. J Bacteriol, 1996 Jun. PMID 8655536, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. a combination of ArcA and AppY antirepression of IscR function, lower levels of IscR, and weak repression by [2Fe-2S]-IscR leads to increased hyaA promoter expression under anaerobic conditions
      Title: ArcA and AppY antagonize IscR repression of hydrogenase-1 expression under anaerobic conditions, revealing a novel mode of O2 regulation of gene expression in Escherichia coli.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to X-ray IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator AppY

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      583681..584430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415096.1 DNA-binding transcriptional activator AppY [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415096.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7U8P0
      Conserved Domains (2) summary
      smart00342
      Location:152 → 233
      HTH_ARAC; helix_turn_helix, arabinose operon control protein
      cl30840
      Location:1 → 230
      PRK09940; transcriptional regulator YdeO; Provisional
    Nucleotide Protein
    Heading Accession and Version

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