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    hicA mRNA interferase toxin HicA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945989, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hicA
    Official Full Name
    mRNA interferase toxin HicA
    Primary source
    ECOCYC:G0-10451
    Locus tag
    b4532
    See related
    ASAP:ABE-0285053
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1431; yncN
    Summary
    YdcQ(HicB) is the antitoxin for the adjacent YncN(HicA) toxin (Jorgensen, 2009). [More information is available at EcoGene: EG14421].
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    Genomic context

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    Sequence:
    NC_000913.3 (1509286..1509462)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 23S rRNA 5-hydroxycytidine C2501 synthase Neighboring gene DUF2554 domain-containing protein YncJ Neighboring gene antitoxin of the HicA-HicB toxin-antitoxin system/ DNA-binding transcriptional repressor HicB Neighboring gene fused putative DNA-binding transcriptional regulator/putative aminotransferase YdcR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The E. coli HicB Antitoxin Contains a Structurally Stable Helix-Turn-Helix DNA Binding Domain. Manav MC, et al. Structure, 2019 Nov 5. PMID 31495532
    2. HicA toxin of Escherichia coli derepresses hicAB transcription to selectively produce HicB antitoxin. Turnbull KJ, et al. Mol Microbiol, 2017 Jun. PMID 28266056
    3. HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. Jørgensen MG, et al. J Bacteriol, 2009 Feb. PMID 19060138, Free PMC Article
    4. Genome-wide screening of genes required for swarming motility in Escherichia coli K-12. Inoue T, et al. J Bacteriol, 2007 Feb. PMID 17122336, Free PMC Article
    5. The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria. Makarova KS, et al. Bioinformatics, 2006 Nov 1. PMID 16895922

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables endonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of growth NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of toxin-antitoxin complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mRNA interferase toxin HicA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1509286..1509462
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415954.2 mRNA interferase toxin HicA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415954.2

      Status: PROVISIONAL

      Conserved Domains (1) summary
      pfam07927
      Location:4 → 56
      HicA_toxin; HicA toxin of bacterial toxin-antitoxin,
    Nucleotide Protein
    Heading Accession and Version

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