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    yegS lipid kinase YegS [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946626, updated on 17-Dec-2024

    Summary

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    Official Symbol
    yegS
    Official Full Name
    lipid kinase YegS
    Primary source
    ECOCYC:G7123
    Locus tag
    b2086
    See related
    ASAP:ABE-0006911
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2082
    Summary
    Lipid kinase activity demonstrated in vitro; physiological role uncertain (Bakali, 2007). [More information is available at EcoGene: EG14367]. YegS is a lipid kinase with phosphatidylglycerol kinase activity in vitro . [More information is available at EcoCyc: G7123].
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    Genomic context

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    Sequence:
    NC_000913.3 (2168712..2169611)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene uncharacterized protein YegR Neighboring gene pseudo Neighboring gene IS3 element protein InsE Neighboring gene IS3 element protein InsF Neighboring gene galactitol-1-phosphate 5-dehydrogenase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Expression, purification, crystallization and preliminary diffraction studies of the mammalian DAG kinase homologue YegS from Escherichia coli. Bakali MA, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2006 Mar 1. PMID 16511327, Free PMC Article
    2. Characterization of Salmonella typhimurium YegS, a putative lipid kinase homologous to eukaryotic sphingosine and diacylglycerol kinases. Nichols CE, et al. Proteins, 2007 Jul 1. PMID 17393457
    3. A 460-kb DNA sequence of the Escherichia coli K-12 genome corresponding to the 40.1-50.0 min region on the linkage map. Itoh T, et al. DNA Res, 1996 Dec 31. PMID 9097040
    4. Global functional atlas of Escherichia coli encompassing previously uncharacterized proteins. Hu P, et al. PLoS Biol, 2009 Apr 28. PMID 19402753, Free PMC Article
    5. Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site. Bakali HM, et al. J Biol Chem, 2007 Jul 6. PMID 17351295

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. yegS is a gene encoding a 32 kDa cytosolic protein with unknown function but with strong sequence homology to a family of uncharacterized eukaryotic non-protein kinases: diacylglycerol kinases. We suggest that there are two protein molecules in the unit.
      Title: Expression, purification, crystallization and preliminary diffraction studies of the mammalian DAG kinase homologue YegS from Escherichia coli.
    2. YegS is related to the human lipid kinases. The crystal structure reveals structural similarity to NAD kinases, and contain a novel metal binding site. Biochemical data suggest that YegS is a phosphatidylglycerol kinase.
      Title: Crystal structure of YegS, a homologue to the mammalian diacylglycerol kinases, reveals a novel regulatory metal binding site.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lipid kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables lipid kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sphingolipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lipid kinase YegS

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2168712..2169611
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416590.1 lipid kinase YegS [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416590.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A1V2GEX4, A0A376M610, Q83VS4
      Conserved Domains (1) summary
      PRK13054
      Location:2 → 299
      PRK13054; lipid kinase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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