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    baeR DNA-binding transcriptional activator BaeR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946605, updated on 3-Dec-2024

    Summary

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    Official Symbol
    baeR
    Official Full Name
    DNA-binding transcriptional activator BaeR
    Primary source
    ECOCYC:EG11618
    Locus tag
    b2079
    See related
    ASAP:ABE-0006884
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2075
    Summary
    Confers novobiocin and deoxycholate resistance via activation of mdtABCD and acrD transcription. [More information is available at EcoGene: EG11618]. The transcriptional regulatory protein BaeR is part of the two-component BaeS/BaeR signal transduction system . [More information is available at EcoCyc: EG11618].
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    Genomic context

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    Sequence:
    NC_000913.3 (2164276..2164998)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene multidrug efflux pump RND permease subunit MdtC Neighboring gene putative multidrug efflux pump MdtD Neighboring gene sensor histidine kinase BaeS Neighboring gene DUF1508 domain-containing protein YegP Neighboring gene tRNA wobble base hydroxylation protein TrhP

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli. Leblanc SK, et al. J Bacteriol, 2011 Jul. PMID 21515766, Free PMC Article
    2. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress. Hu L, et al. Microb Pathog, 2020 Oct. PMID 32603765
    3. The BaeSR two-component regulatory system mediates resistance to condensed tannins in Escherichia coli. Zoetendal EG, et al. Appl Environ Microbiol, 2008 Jan. PMID 18039828, Free PMC Article
    4. Involvement of multiple transcription factors for metal-induced spy gene expression in Escherichia coli. Yamamoto K, et al. J Biotechnol, 2008 Jan 20. PMID 17884222
    5. Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system. Nishino K, et al. J Bacteriol, 2005 Mar. PMID 15716448, Free PMC Article

    See all (29) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
      Title: BaeSR activates type VI secretion system expression in porcine extra-intestinal pathogenic Escherichia coli to enhance bacterial resistance to zinc stress.
    2. The authors hypothesize that the main function of the BaeSR-mediated response is to upregulate efflux pump expression in response to specific envelope-damaging agents.
      Title: Characterization of the induction and cellular role of the BaeSR two-component envelope stress response of Escherichia coli.
    3. transcriptomic data identified the global transcription regulators ArcA, CRP, Fis, FNR, Fur, BaeR, CpxR, and IHF as targets and potential CO sensors
      Title: Carbon monoxide-releasing antibacterial molecules target respiration and global transcriptional regulators.
    4. To understand the whole picture of BaeSR regulation, a DNA microarray analysis of the effect of BaeR overproduction was performed.
      Title: Genome-wide analyses of Escherichia coli gene expression responsive to the BaeSR two-component regulatory system.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphorelay response regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription cis-regulatory region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphorelay signal transduction system IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of DNA-templated transcription initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of response to drug IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of protein-DNA complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    DNA-binding transcriptional activator BaeR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2164276..2164998
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416583.1 DNA-binding transcriptional activator BaeR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416583.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QA26, A0A8S0FR97, A0A8S7EDV7
      Conserved Domains (1) summary
      PRK10710
      Location:1 → 240
      PRK10710; DNA-binding transcriptional regulator BaeR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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