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    mprA DNA-binding transcriptional regulator MprA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945282, updated on 17-Dec-2024

    Summary

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    Official Symbol
    mprA
    Official Full Name
    DNA-binding transcriptional regulator MprA
    Primary source
    ECOCYC:EG10603
    Locus tag
    b2684
    See related
    ASAP:ABE-0008834
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2678; emrR
    Summary
    The "Escherichia coli multidrug resistance regulator" , EmrR, negatively regulates the transcription of genes that code for multidrug resistance pumps that extrude structurally unrelated antimicrobial agents from the cell and possibly it also represses a gene that codes for a porin . [More information is available at EcoCyc: EG10603].
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    Genomic context

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    Sequence:
    NC_000913.3 (2810770..2811300)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene L-valine exporter, YgaZ component Neighboring gene L-valine exporter, YgaH component Neighboring gene multidrug efflux pump membrane fusion protein EmrA Neighboring gene multidrug efflux pump membrane subunit EmrB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A new family of low molecular weight antibiotics from enterobacteria. Asensio C, et al. Biochem Biophys Res Commun, 1976 Mar 8. PMID 4071
    2. mprA, an Escherichia coli gene that reduces growth-phase-dependent synthesis of microcins B17 and C7 and blocks osmoinduction of proU when cloned on a high-copy-number plasmid. del Castillo I, et al. J Bacteriol, 1990 Jan. PMID 2152912, Free PMC Article
    3. Overlaps and parallels in the regulation of intrinsic multiple-antibiotic resistance in Escherichia coli. Miller PF, et al. Mol Microbiol, 1996 Aug. PMID 8866468
    4. Expression of a Butyrivibrio fibrisolvens E14 gene (cinB) encoding an enzyme with cinnamoyl ester hydrolase activity is negatively regulated by the product of an adjacent gene (cinR). Dalrymple BP, et al. Microbiology (Reading), 1997 Apr. PMID 9141683
    5. Comparative approach to analysis of regulation in complete genomes: multidrug resistance systems in gamma-proteobacteria. Rodionov DA, et al. J Mol Microbiol Biotechnol, 2001 Apr. PMID 11321589

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Polyamines are involved in easing of oxidative stress through stimulation of synthesis of SoxR, EmrR and GshA together with RpoS.
      Title: Three members of polyamine modulon under oxidative stress conditions: two transcription factors (SoxR and EmrR) and a glutathione synthetic enzyme (GshA).
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to antibiotic IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA-binding transcriptional regulator MprA

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2810770..2811300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417169.1 DNA-binding transcriptional regulator MprA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417169.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6C9QFV1, W1EUT9
      Conserved Domains (1) summary
      PRK10870
      Location:1 → 176
      PRK10870; transcriptional repressor MprA; Provisional
    Nucleotide Protein
    Heading Accession and Version

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