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    fdhF formate dehydrogenase H [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948584, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fdhF
    Official Full Name
    formate dehydrogenase H
    Primary source
    ECOCYC:EG10285
    Locus tag
    b4079
    See related
    ASAP:ABE-0013363
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    chlF; ECK4072
    Summary
    Formate dehydrogenase-H is one of three formate dehydrogenases in Escherichia coli . [More information is available at EcoCyc: EG10285].
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    Genomic context

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    Sequence:
    NC_000913.3 (4297219..4299366, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene glutamate/aspartate : H(+) symporter GltP Neighboring gene Sel1 repeat-containing protein YjcO Neighboring gene putative multidrug efflux pump outer membrane channel Neighboring gene putative multidrug efflux pump subunit MdtO Neighboring gene putative multidrug efflux pump membrane fusion protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the product of the cloned fdhF gene of Escherichia coli. Wu LF, et al. J Gen Microbiol, 1987 Sep. PMID 2834507
    2. Selenium-containing formate dehydrogenase H from Escherichia coli: a molybdopterin enzyme that catalyzes formate oxidation without oxygen transfer. Khangulov SV, et al. Biochemistry, 1998 Mar 10. PMID 9521673
    3. Crystal structure of formate dehydrogenase H: catalysis involving Mo, molybdopterin, selenocysteine, and an Fe4S4 cluster. Boyington JC, et al. Science, 1997 Feb 28. PMID 9036855
    4. Interaction of the Escherichia coli fdhF mRNA hairpin promoting selenocysteine incorporation with the ribosome. Hüttenhofer A, et al. Nucleic Acids Res, 1996 Oct 15. PMID 8918790, Free PMC Article
    5. Coordination of selenium to molybdenum in formate dehydrogenase H from Escherichia coli. Gladyshev VN, et al. Proc Natl Acad Sci U S A, 1994 Aug 2. PMID 8052647, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Urate-degrading activity has been identified in E. coli that is operational under microaerobic and anaerobic conditions. This activity requires formate, formate dehydrogenase H, and either aegA or ygfT.
      Title: Identification of a Formate-Dependent Uric Acid Degradation Pathway in Escherichia coli.
    2. fDH and Hyd enzymes have impact on the FO F1 -ATPase activity depending on external pH and potassium ions
      Title: Understanding the Role of Escherichia coli Hydrogenases and Formate Dehydrogenases in the F(O) F(1) -ATPase Activity during the Mixed Acid Fermentation of Mixture of Carbon Sources.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Escherichia coli formate-hydrogen lyase. Purification and properties of the selenium-dependent formate dehydrogenase component.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to NADH dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables formate dehydrogenase (NAD+) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molybdopterin cofactor binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables molybdopterin cofactor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaerobic electron transport chain IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic electron transport chain NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in anaerobic respiration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaerobic respiration NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cellular respiration IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formate metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in formate oxidation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in formate oxidation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in glucose catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in glucose catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in respiratory electron transport chain IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within urate catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of formate dehydrogenase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of formate dehydrogenase complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    part_of oxidoreductase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    formate dehydrogenase H

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4297219..4299366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418503.1 formate dehydrogenase H [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418503.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A828MW10
      Conserved Domains (1) summary
      TIGR01591
      Location:6 → 685
      Fdh-alpha; formate dehydrogenase, alpha subunit, archaeal-type
    Nucleotide Protein
    Heading Accession and Version

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