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    galE UDP-glucose 4-epimerase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945354, updated on 3-Dec-2024

    Summary

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    Official Symbol
    galE
    Official Full Name
    UDP-glucose 4-epimerase
    Primary source
    ECOCYC:EG10362
    Locus tag
    b0759
    See related
    ASAP:ABE-0002575
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0748; galD
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    Genomic context

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    Sequence:
    NC_000913.3 (791039..792055, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene galactose-1-epimerase Neighboring gene galactokinase Neighboring gene galactose-1-phosphate uridylyltransferase Neighboring gene ABC family protein ModF Neighboring gene DNA-binding transcriptional dual regulator ModE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Crystal structures of the oxidized and reduced forms of UDP-galactose 4-epimerase isolated from Escherichia coli. Thoden JB, et al. Biochemistry, 1996 Feb 27. PMID 8611559
    2. UDP-galactose 4-epimerase. Phosphorus-31 nuclear magnetic resonance analysis of NAD+ and NADH bound at the active site. Konopka JM, et al. Biochemistry, 1989 Mar 21. PMID 2659075
    3. Translation of galE and coordination of galactose operon expression in Escherichia coli: effects of insertions and deletions in the non-translated leader sequence. Bingham AH, et al. Mol Microbiol, 1987 Jul. PMID 2838723
    4. An arginine residue is essential for stretching and binding of the substrate on UDP-glucose-4-epimerase from Escherichia coli. Use of a stacked and quenched uridine nucleotide fluorophore as probe. Bhattacharyya U, et al. J Biol Chem, 1999 May 21. PMID 10329648
    5. Dramatic differences in the binding of UDP-galactose and UDP-glucose to UDP-galactose 4-epimerase from Escherichia coli. Thoden JB, et al. Biochemistry, 1998 Aug 18. PMID 9708982

    See all (94) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced susceptibility to antiseptics is conferred by heterologous housekeeping genes, fabI and galE.
      Title: Reduced Susceptibility to Antiseptics Is Conferred by Heterologous Housekeeping Genes.
    2. co-translational maturation of the GalE N-terminal domain influences ribosome pausing and subsequent tmRNA activity
      Title: The N-terminus of GalE induces tmRNA activity in Escherichia coli.
    3. N-terminus verified by Edman degradation on complete protein
      Title: Amounts of proteins altered by mutations in the dnaA gene of Escherichia coli.
    4. we located the traditional galE gene in the gal operon of O86:B7, which can catalyze the interconversion of UDP-Glc to UDP-Gal.
      Title: Three UDP-hexose 4-epimerases with overlapping substrate specificity coexist in E. coli O86:B7.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables NAD+ binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 4-epimerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables UDP-glucose 4-epimerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables UDP-glucose 4-epimerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables racemase and epimerase activity, acting on carbohydrates and derivatives IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within carbohydrate metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within colanic acid biosynthetic process IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within colanic acid biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within galactose catabolic process via UDP-galactose IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within galactose metabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in galactose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within galactose metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in monosaccharide metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    UDP-glucose 4-epimerase
    NP_415280.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      791039..792055 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415280.3 UDP-glucose 4-epimerase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415280.3

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A765X5B7
      Conserved Domains (1) summary
      PRK10675
      Location:1 → 338
      PRK10675; UDP-galactose-4-epimerase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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