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    hemC hydroxymethylbilane synthase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 947759, updated on 3-Dec-2024

    Summary

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    Official Symbol
    hemC
    Official Full Name
    hydroxymethylbilane synthase
    Primary source
    ECOCYC:EG10429
    Locus tag
    b3805
    See related
    ASAP:ABE-0012427
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3799; popE
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    Genomic context

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    Sequence:
    NC_000913.3 (3989825..3990766, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene protein HemY Neighboring gene PF04375 family protein HemX Neighboring gene uroporphyrinogen-III synthase Neighboring gene adenylate cyclase Neighboring gene frataxin CyaY Neighboring gene protein YzcX

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of porphobilinogen deaminase reveals a flexible multidomain polymerase with a single catalytic site. Louie GV, et al. Nature, 1992 Sep 3. PMID 1522882
    2. Mutagenesis of arginine residues in the catalytic cleft of Escherichia coli porphobilinogen deaminase that affects dipyrromethane cofactor assembly and tetrapyrrole chain initiation and elongation. Jordan PM, et al. Biochem J, 1991 Dec 1. PMID 1747120, Free PMC Article
    3. Investigation of putative active-site lysine residues in hydroxymethylbilane synthase. Preparation and characterization of mutants in which (a) Lys-55, (b) Lys-59 and (c) both Lys-55 and Lys-59 have been replaced by glutamine. Hädener A, et al. Biochem J, 1990 Oct 15. PMID 2122889, Free PMC Article
    4. Evidence that pyridoxal phosphate modification of lysine residues (Lys-55 and Lys-59) causes inactivation of hydroxymethylbilane synthase (porphobilinogen deaminase). Miller AD, et al. Biochem J, 1989 Aug 15. PMID 2510713, Free PMC Article
    5. Purification, crystallization and properties of porphobilinogen deaminase from a recombinant strain of Escherichia coli K12. Jordan PM, et al. Biochem J, 1988 Sep 1. PMID 3052434, Free PMC Article

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: Purification, crystallization and properties of porphobilinogen deaminase from a recombinant strain of Escherichia coli K12.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables hydroxymethylbilane synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylbilane synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydroxymethylbilane synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxymethylbilane synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in heme biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within heme biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in porphyrin-containing compound biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protoporphyrinogen IX biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protoporphyrinogen IX biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tetrapyrrole biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within tetrapyrrole biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hydroxymethylbilane synthase
    YP_026260.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3989825..3990766 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_026260.1 hydroxymethylbilane synthase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_026260.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A0H3PYP8, B1LLX5
      Conserved Domains (1) summary
      PRK00072
      Location:4 → 296
      hemC; porphobilinogen deaminase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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