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    ghoT toxin of the GhoTS toxin-antitoxin system [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 1450308, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ghoT
    Official Full Name
    toxin of the GhoTS toxin-antitoxin system
    Primary source
    ECOCYC:G0-10472
    Locus tag
    b4559
    See related
    ASAP:ABE-0285080
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK4122; yjdO
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    Genomic context

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    Sequence:
    NC_000913.3 (4352908..4353081)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative N-acetyltransferase YjdJ Neighboring gene antitoxin of the GhoTS toxin-antitoxin system Neighboring gene lysine--tRNA ligase/Ap4A synthetase/Ap3A synthetase Neighboring gene dipeptide/tripeptide:H(+) symporter DtpC

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress. Cheng HY, et al. Environ Microbiol, 2014 Jun. PMID 24373067
    2. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article
    3. The complete genome sequence of Escherichia coli K-12. Blattner FR, et al. Science, 1997 Sep 5. PMID 9278503
    4. Escherichia coli K-12: a cooperatively developed annotation snapshot--2005. Riley M, et al. Nucleic Acids Res, 2006. PMID 16397293, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. GhoT reduces metabolism by reducing ATP and proton motive force and that this reduction in metabolism is important for growth with various antimicrobials.
      Title: Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Component Evidence Code Pubs
    located_in cell pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    toxin of the GhoTS toxin-antitoxin system

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4352908..4353081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_588474.1 toxin of the GhoTS toxin-antitoxin system [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for YP_588474.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P64646
      Conserved Domains (1) summary
      pfam10753
      Location:4 → 57
      Toxin_GhoT_OrtT; Toxin GhoT_OrtT
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

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