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    leuL leu operon leader peptide [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946072, updated on 3-Dec-2024

    Summary

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    Official Symbol
    leuL
    Official Full Name
    leu operon leader peptide
    Primary source
    ECOCYC:EG11280
    Locus tag
    b0075
    See related
    ASAP:ABE-0000269
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0077; leuIP; leulL; leulLP; leuLP
    Summary
    Based on a putative adjacent terminator, observed transcription termination in vitro, demonstrated regulation by attenuation of the similar Salmonella operon, and the presence of four leucines within its sequence, LeuL is presumed to be a leader peptide involved in attenuation of transcription of the leuLABCD operon in response to leucine abundance . [More information is available at EcoCyc: EG11280].
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    Genomic context

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    Sequence:
    NC_000913.3 (83622..83708, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene 3-isopropylmalate dehydrogenase Neighboring gene 2-isopropylmalate synthase Neighboring gene DNA-binding transcriptional dual regulator LeuO Neighboring gene protein YabR

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Control of leu operon expression in Escherichia coli by a transcription attenuation mechanism. Wessler SR, et al. J Mol Biol, 1981 Jul 15. PMID 6171647
    2. Genetic fine structure of the leucine operon of Escherichia coli K-12. Somers JM, et al. J Bacteriol, 1973 Mar. PMID 4570778, Free PMC Article
    3. Experimental and computational assessment of conditionally essential genes in Escherichia coli. Joyce AR, et al. J Bacteriol, 2006 Dec. PMID 17012394, Free PMC Article
    4. Small membrane proteins found by comparative genomics and ribosome binding site models. Hemm MR, et al. Mol Microbiol, 2008 Dec. PMID 19121005, Free PMC Article
    5. Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110. Hayashi K, et al. Mol Syst Biol, 2006. PMID 16738553, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Gene Ontology Provided by EcoCyc

    Process Evidence Code Pubs
    involved_in L-leucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    leu operon leader peptide

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      83622..83708 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414617.1 leu operon leader peptide [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414617.1

      Status: PROVISIONAL

      Conserved Domains (1) summary
      PRK09925
      Location:1 → 28
      PRK09925; leu operon leader peptide; Provisional
    Nucleotide Protein
    Heading Accession and Version

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