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    manX mannose-specific PTS enzyme IIAB component [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946334, updated on 3-Dec-2024

    Summary

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    Official Symbol
    manX
    Official Full Name
    mannose-specific PTS enzyme IIAB component
    Primary source
    ECOCYC:EG10567
    Locus tag
    b1817
    See related
    ASAP:ABE-0006054
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1815; gptB; mpt; ptsL; ptsX
    Summary
    HT_Cmplx16_Mem: [More information is available at EcoGene: EG10567]. This subunit contains PTS Enzyme IIA and IIB domains. [More information is available at EcoCyc: EG10567].
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    Genomic context

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    Sequence:
    NC_000913.3 (1902048..1903019)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative c-di-GMP phosphodiesterase PdeD Neighboring gene TerC family inner membrane protein YoaE Neighboring gene protein YoaL Neighboring gene mannose-specific PTS enzyme IIC component Neighboring gene mannose-specific PTS enzyme IID component

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. 13C-detected HN(CA)C and HMCMC experiments using a single methyl-reprotonated sample for unambiguous methyl resonance assignment. Hu K, et al. J Biomol NMR, 2006 Dec. PMID 17036159
    2. Secondary structure of the IIB domain of the Escherichia coli mannose transporter, a new fold in the class of alpha/beta twisted open-sheet structures. Gschwind RM, et al. FEBS Lett, 1997 Mar 3. PMID 9074635
    3. Mannose permease of Escherichia coli. Domain structure and function of the phosphorylating subunit. Erni B, et al. J Biol Chem, 1989 Nov 5. PMID 2681202
    4. Solution NMR structure of the 48-kDa IIAMannose-HPr complex of the Escherichia coli mannose phosphotransferase system. Williams DC Jr, et al. J Biol Chem, 2005 May 27. PMID 15788390, Free PMC Article
    5. Predicted topology of the N-terminal domain of the hydrophilic subunit of the mannose transporter of Escherichia coli. Marković-Housley Z, et al. FEBS Lett, 1994 Mar 7. PMID 8131846

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on mature peptide
      Title: Acid- and base-induced proteins during aerobic and anaerobic growth of Escherichia coli revealed by two-dimensional gel electrophoresis.
    2. solution structure of a stably phosphorylated form of the cytoplasmic B domain of (IIB(Mtl)) of the E coli phosphotransferase system, containing a mutation of the active site Cys384 to Ser, solved by NMR
      Title: Visualization of the phosphorylated active site loop of the cytoplasmic B domain of the mannitol transporter II(Mannitol) of the Escherichia coli phosphotransferase system by NMR spectroscopy and residual dipolar couplings.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein-N(PI)-phosphohistidine-sugar phosphotransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-N(PI)-phosphohistidine-sugar phosphotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within D-glucose import across plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within N-acetylglucosamine transport EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within fructose import across plasma membrane EXP
    Inferred from Experiment
    more info
    		 PubMed 
    acts_upstream_of_or_within mannose transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mannose transmembrane transport NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in phosphoenolpyruvate-dependent sugar phosphotransferase system IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transmembrane transporter complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transmembrane transporter complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mannose-specific PTS enzyme IIAB component
    NP_416331.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1902048..1903019
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416331.1 mannose-specific PTS enzyme IIAB component [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416331.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A6N8NE64, A0A8S7XW71
      Conserved Domains (1) summary
      PRK15088
      Location:1 → 321
      PRK15088; PTS system mannose-specific transporter subunits IIAB; Provisional
    Nucleotide Protein
    Heading Accession and Version

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