parC DNA topoisomerase IV subunit A [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

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Official Symbol: parC
Official Full Name: DNA topoisomerase IV subunit A
Primary source: ECOCYC:EG10686
Locus tag: b3019
See related: ASAP:ABE-0009916
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK3010
Summary: ParC physically interacts with SeqA. [More information is available at EcoGene: EG10686]. The purified ParC protein is a dimer in solution . [More information is available at EcoCyc: EG10686].
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Genomic context

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Sequence:: NC_000913.3 (3163715..3165973, complement)

NC_000913.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_000913.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli.
Title: Topoisomerase IV tracks behind the replication fork and the SeqA complex during DNA replication in Escherichia coli.
Supercoiling, R-loops, Replication and the Functions of Bacterial Type 1A Topoisomerases.
Title: Supercoiling, R-loops, Replication and the Functions of Bacterial Type 1A Topoisomerases.
High frequency of aac(6')-Ib-cr gene associated with double mutations in gyrA and parC is related to fluoroquinolone resistance
Title: High frequency of aac(6')-Ib-cr gene associated with double mutations in gyrA and parC in Escherichia coli isolates from patients with urinary tract infections.
Among nalidixic acid resistant isolates 13 (28%) showed presence of single nucleotide polymorphism (SNP) in parC (C330-T330).
Title: Characterization of enteropathogenic Escherichia coli of clinical origin from the pediatric population in Pakistan.
Impairing the TopoIV-MukBEF interaction delays sister ter segregation in cells lacking MatP.
Title: MatP regulates the coordinated action of topoisomerase IV and MukBEF in chromosome segregation.
MukB-ParC interaction may play a role in chromosome organization rather than in separation of daughter chromosomes
Title: The MukB-ParC interaction affects the intramolecular, not intermolecular, activities of topoisomerase IV.
acquisition of a fourth resistance mutation significantly increased fitness especially with the addition of a parC mutation (Topoisomerase IV) to a low-fitness strain carrying resistance mutations in gyrA (DNA Gyrase) and marR (drug efflux regulation).
Title: Interplay in the selection of fluoroquinolone resistance and bacterial fitness.
the centromere-like parC DNA is wrapped around a ParR protein scaffold and works with ParM polymerization to drive active DNA transport during plasmid partition
Title: Structural analysis of the ParR/parC plasmid partition complex.
QnrA binds to topoisomerase IV and its subunits in a reaction that does not depend on the presence of DNA, quinolone, or ATP.
Title: Interaction of the plasmid-encoded quinolone resistance protein QnrA with Escherichia coli topoisomerase IV.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by EcoCyc

Function	Evidence Code	Pubs
enables ATP binding	IBA Inferred from Biological aspect of Ancestor more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA negative supercoiling activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA topoisomerase activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA topoisomerase activity	IEA Inferred from Electronic Annotation more info
contributes_to DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA topological change	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within DNA topological change	IDA Inferred from Direct Assay more info	PubMed
involved_in DNA topological change	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within chromosome segregation	IDA Inferred from Direct Assay more info	PubMed
involved_in chromosome segregation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within plasmid partitioning	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	IDA Inferred from Direct Assay more info	PubMed
part_of DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex	NAS Non-traceable Author Statement more info	PubMed
located_in chromosome	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in extrinsic component of plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: DNA topoisomerase IV subunit A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_000913.3 Reference assembly

Range

3163715..3165973 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_417491.1 DNA topoisomerase IV subunit A [Escherichia coli str. K-12 substr. MG1655]

See identical proteins and their annotated locations for NP_417491.1

Status: PROVISIONAL

UniProtKB/TrEMBL

A0A376TRX9

Conserved Domains (2) summary

TIGR01062
Location:5 → 738

parC_Gneg; DNA topoisomerase IV, A subunit, proteobacterial

sd00041
Location:499 → 538

GyrA-ParC_C; GyrA_CTD repeat [structural motif]