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    purU formyltetrahydrofolate deformylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945827, updated on 3-Dec-2024

    Summary

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    Official Symbol
    purU
    Official Full Name
    formyltetrahydrofolate deformylase
    Primary source
    ECOCYC:EG11819
    Locus tag
    b1232
    See related
    ASAP:ABE-0004138
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK1227; tgs; ychI
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    Genomic context

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    Sequence:
    NC_000913.3 (1287782..1288624, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene tRNA-Tyr Neighboring gene tRNA-Tyr Neighboring gene NTF2-like domain-containing protein YchJ Neighboring gene putative patatin-like phospholipase RssA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Assembly of an active enzyme by the linkage of two protein modules. Nixon AE, et al. Proc Natl Acad Sci U S A, 1997 Feb 18. PMID 9037007, Free PMC Article
    2. Genetic map of the tyrT region of Escherichia coli from 27.1 to 27.7 minutes based exclusively on sequence data. Bösl MR. J Bacteriol, 1993 Dec. PMID 8244954, Free PMC Article
    3. A novel RNA product of the tyrT operon of Escherichia coli. Bösl M, et al. Nucleic Acids Res, 1991 Nov 11. PMID 1840671, Free PMC Article
    4. The tyrT locus of Escherichia coli exhibits a regulatory function for glycine metabolism. Michelsen U, et al. J Bacteriol, 1989 Nov. PMID 2681148, Free PMC Article
    5. Organization and functions of genes in the upstream region of tyrT of Escherichia coli: phenotypes of mutants with partial deletion of a new gene (tgs). Bösl M, et al. J Bacteriol, 1994 Jan. PMID 8282700, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. N-terminus verified by Edman degradation on complete protein
      Title: purU, a source of formate for purT-dependent phosphoribosyl-N-formylglycinamide synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables formyltetrahydrofolate deformylase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables formyltetrahydrofolate deformylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in one-carbon metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within one-carbon metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in protein hexamerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    formyltetrahydrofolate deformylase
    NP_415748.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      1287782..1288624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415748.1 formyltetrahydrofolate deformylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415748.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9AJA6
      Conserved Domains (1) summary
      PRK06027
      Location:1 → 280
      purU; formyltetrahydrofolate deformylase; Reviewed
    Nucleotide Protein
    Heading Accession and Version

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