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    tolR Tol-Pal system protein TolR [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945328, updated on 3-Dec-2024

    Summary

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    Official Symbol
    tolR
    Official Full Name
    Tol-Pal system protein TolR
    Primary source
    ECOCYC:EG11011
    Locus tag
    b0738
    See related
    ASAP:ABE-0002513
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0727
    Summary
    TolR is anchored to the inner membrane by a single TM segment and extends into the periplasm. [More information is available at EcoGene: EG11011]. TolR is one of three (along with TolA and TolQ) inner membrane protein members of the YbgC-YbgF-TolQ-R-A-B-Pal Cell Envelope Complex, also known as the Tol-Pal system. [More information is available at EcoCyc: EG11011].
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    Genomic context

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    Sequence:
    NC_000913.3 (775849..776277)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene cytochrome bd-I accessory subunit CydX Neighboring gene PF09600 family protein YbgE Neighboring gene esterase/thioesterase Neighboring gene Tol-Pal system protein TolQ Neighboring gene Tol-Pal system protein TolA Neighboring gene Tol-Pal system periplasmic protein TolB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure and function of the Escherichia coli Tol-Pal stator protein TolR. Wojdyla JA, et al. J Biol Chem, 2015 Oct 30. PMID 26354441, Free PMC Article
    2. Direct interaction between fd phage pilot protein pIII and the TolQ-TolR proton-dependent motor provides new insights into the import of filamentous phages. Pellegri C, et al. J Biol Chem, 2023 Aug. PMID 37451481, Free PMC Article
    3. Role of TolR N-terminal, central, and C-terminal domains in dimerization and interaction with TolA and tolQ. Journet L, et al. J Bacteriol, 1999 Aug. PMID 10419942, Free PMC Article
    4. Membrane topology of the Escherichia coli TolR protein required for cell envelope integrity. Muller MM, et al. J Bacteriol, 1993 Sep. PMID 8376353, Free PMC Article
    5. Membrane topologies of the TolQ and TolR proteins of Escherichia coli: inactivation of TolQ by a missense mutation in the proposed first transmembrane segment. Kampfenkel K, et al. J Bacteriol, 1993 Jul. PMID 8331075, Free PMC Article

    See all (50) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Direct interaction between fd phage pilot protein pIII and the TolQ-TolR proton-dependent motor provides new insights into the import of filamentous phages.
      Title: Direct interaction between fd phage pilot protein pIII and the TolQ-TolR proton-dependent motor provides new insights into the import of filamentous phages.
    2. TolR and full-length OmpA bind and maintain the local structure of the E. coli cell wall even in the absence of peptidoglycan.
      Title: Binding from Both Sides: TolR and Full-Length OmpA Bind and Maintain the Local Structure of the E. coli Cell Wall.
    3. Structure and function of the Escherichia coli Tol-Pal stator protein TolR has been described.
      Title: Structure and function of the Escherichia coli Tol-Pal stator protein TolR.
    4. Using a combination of in vivo coimmunoprecipitations and in vitro pulldown experiments, we demonstrated that KT interacts with the TolA, TolB, and TolR proteins.
      Title: Interaction of the colicin K bactericidal toxin with components of its import machinery in the periplasm of Escherichia coli.
    5. Mapping the interactions between escherichia coli tol subunits: rotation of the TolR transmembrane helix.
      Title: Mapping the interactions between escherichia coli tol subunits: rotation of the TolR transmembrane helix.
    6. Data show that movements of the TolR C-terminal domain depend on TolQR ionizable key residues and regulate activity of the Tol complex.
      Title: Movements of the TolR C-terminal domain depend on TolQR ionizable key residues and regulate activity of the Tol complex.
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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within bacteriocin transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within cell division EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell division NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within cell septum assembly EXP
    Inferred from Experiment
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of membrane invagination NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell division site IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tol-Pal system protein TolR

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      775849..776277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415266.1 Tol-Pal system protein TolR [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415266.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      W1X3J1
      Conserved Domains (1) summary
      PRK11024
      Location:11 → 142
      PRK11024; colicin uptake protein TolR; Provisional
    Nucleotide Protein
    Heading Accession and Version

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