tyrA fused chorismate mutase/prephenate dehydrogenase [Escherichia coli str. K-12 substr. MG1655] - Gene

Summary

Official Symbol: tyrA
Official Full Name: fused chorismate mutase/prephenate dehydrogenase
Primary source: ECOCYC:EG11039
Locus tag: b2600
See related: ASAP:ABE-0008547
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
Lineage: Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
Also known as: ECK2597
Summary: Bifunctional protein, mutase is N-terminal domain. [More information is available at EcoGene: EG11039]. Bifunctional chorismate mutase / prephenate dehydrogenase (TyrA) carries out the shared first step in the parallel biosynthetic pathways for the aromatic amino acids tyrosine and phenylalanine, as well as the second step in tyrosine biosynthesis. [More information is available at EcoCyc: EG11039].
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NC_000913.3 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables chorismate mutase activity	IDA Inferred from Direct Assay more info	PubMed
enables chorismate mutase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables prephenate dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables prephenate dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables prephenate dehydrogenase (NAD+) activity	IEA Inferred from Electronic Annotation more info
enables prephenate dehydrogenase (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within L-phenylalanine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in carboxylic acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chorismate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in tyrosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within tyrosine biosynthetic process	IDA Inferred from Direct Assay more info	PubMed
involved_in tyrosine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

NP_417091.1

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The following sections contain reference sequences that belong to a specific genome build. Explain