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    ubiG bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 946607, updated on 3-Dec-2024

    Summary

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    Official Symbol
    ubiG
    Official Full Name
    bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase
    Primary source
    ECOCYC:EG11143
    Locus tag
    b2232
    See related
    ASAP:ABE-0007374
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2224; pufX; yfaB
    Summary
    The ubiG gene product is an O-methyltransferase that catalyzes both O-methylation reactions in the biosynthesis of ubiquinone. [More information is available at EcoCyc: EG11143].
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    Genomic context

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    Sequence:
    NC_000913.3 (2339567..2340289)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1175 domain-containing protein YfaT Neighboring gene DUF2138 domain-containing protein YfaA Neighboring gene DNA gyrase subunit A Neighboring gene putative autotransporter adhesin YfaL Neighboring gene protein YpaB

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Membrane-associated reactions in ubiquinone biosynthesis. 2-Octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone methyltransferase. Leppik RA, et al. Biochim Biophys Acta, 1976 Mar 25. PMID 769831
    2. Ubiquinone accumulation improves osmotic-stress tolerance in Escherichia coli. Sévin DC, et al. Nat Chem Biol, 2014 Apr. PMID 24509820
    3. Crystallization and preliminary crystallographic studies of UbiG, an O-methyltransferase from Escherichia coli. Xing L, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2011 Jun 1. PMID 21636923, Free PMC Article
    4. Regulation of ubiG gene expression in Escherichia coli. Gibert I, et al. J Bacteriol, 1988 Mar. PMID 2830238, Free PMC Article
    5. Mutants of Escherichia coli K-12 blocked in the final reaction of ubiquinone biosynthesis: characterization and genetic analysis. Stroobant P, et al. J Bacteriol, 1972 Jan. PMID 4333375, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables 2-polyprenyl-6-hydroxyphenol methylase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 3-demethylubiquinol-n 3-O-methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatidylglycerol binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within hyperosmotic salinity response IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ubiquinone biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquinone biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic side of plasma membrane IC
    Inferred by Curator
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ubiquinone biosynthesis complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase
    NP_416735.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      2339567..2340289
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_416735.1 bifunctional 3-demethylubiquinone-8 3-O-methyltransferase and 2-octaprenyl-6-hydroxyphenol methylase [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_416735.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EAC5
      Conserved Domains (1) summary
      PRK05134
      Location:9 → 240
      PRK05134; bifunctional 2-polyprenyl-6-hydroxyphenol methylase/3-demethylubiquinol 3-O-methyltransferase UbiG
    Nucleotide Protein
    Heading Accession and Version

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