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    fadM long-chain acyl-CoA thioesterase FadM [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945812, updated on 3-Dec-2024

    Summary

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    Official Symbol
    fadM
    Official Full Name
    long-chain acyl-CoA thioesterase FadM
    Primary source
    ECOCYC:G6244
    Locus tag
    b0443
    See related
    ASAP:ABE-0001537
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0437; tesC; ybaW
    Summary
    3,5-tetradecadienoyl-CoA is the preferred substrate for thioesterase III, which is induced by fatty acids, suggesting a role in beta-oxidation of fatty acids (Nie, 2008). [More information is available at EcoGene: EG13251]. Thioesterase III is a long-chain acyl-CoA thioesterase that is involved in the -oxidation of oleic acid. [More information is available at EcoCyc: G6244].
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    Genomic context

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    Sequence:
    NC_000913.3 (464402..464800)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene periplasmic folding chaperone Neighboring gene helix-hairpin-helix 3 family protein Neighboring gene 7-cyano-7-deazaguanine synthase Neighboring gene uncharacterized protein YbaE

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. An alternative pathway of oleate beta-oxidation in Escherichia coli involving the hydrolysis of a dead end intermediate by a thioesterase. Ren Y, et al. J Biol Chem, 2004 Mar 19. PMID 14707139
    2. A novel paradigm of fatty acid beta-oxidation exemplified by the thioesterase-dependent partial degradation of conjugated linoleic acid that fully supports growth of Escherichia coli. Nie L, et al. Biochemistry, 2008 Sep 9. PMID 18702504
    3. Analysis of proteins with the 'hot dog' fold: prediction of function and identification of catalytic residues of hypothetical proteins. Pidugu LS, et al. BMC Struct Biol, 2009 May 28. PMID 19473548, Free PMC Article
    4. Identification and characterization of Escherichia coli thioesterase III that functions in fatty acid beta-oxidation. Nie L, et al. Biochemistry, 2008 Jul 22. PMID 18576672
    5. A new member of the Escherichia coli fad regulon: transcriptional regulation of fadM (ybaW). Feng Y, et al. J Bacteriol, 2009 Oct. PMID 19684132, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables fatty acyl-CoA hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables fatty acyl-CoA hydrolase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiolester hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within fatty acid beta-oxidation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    long-chain acyl-CoA thioesterase FadM

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      464402..464800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_414977.1 long-chain acyl-CoA thioesterase FadM [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_414977.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A2H4TPI9, A0A895NSL2
      Conserved Domains (1) summary
      TIGR00051
      Location:5 → 120
      TIGR00051; acyl-CoA thioester hydrolase, YbgC/YbaW family
    Nucleotide Protein
    Heading Accession and Version

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