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    rihA pyrimidine-specific ribonucleoside hydrolase RihA [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 945503, updated on 3-Dec-2024

    Summary

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    Official Symbol
    rihA
    Official Full Name
    pyrimidine-specific ribonucleoside hydrolase RihA
    Primary source
    ECOCYC:G6358
    Locus tag
    b0651
    See related
    ASAP:ABE-0002227
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK0644; ybeK
    Summary
    The rihA gene encodes a ribonucleoside hydrolase that preferentially utilizes cytidine and uridine . [More information is available at EcoCyc: G6358].
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    Genomic context

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    Sequence:
    NC_000913.3 (683477..684412, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DUF1266 domain-containing protein YbeU Neighboring gene co-chaperone DjlC Neighboring gene chaperone protein HscC Neighboring gene glutamate/aspartate ABC transporter ATP binding subunit Neighboring gene glutamate/aspartate ABC transporter membrane subunit GltK Neighboring gene glutamate/aspartate ABC transporter membrane subunit GltJ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Active site plasticity revealed from the structure of the enterobacterial N-ribohydrolase RihA bound to a competitive inhibitor. Garau G, et al. BMC Struct Biol, 2010 Jun 8. PMID 20529317, Free PMC Article
    2. New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product. Muzzolini L, et al. Biochemistry, 2006 Jan 24. PMID 16411753
    3. The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation. Petersen C, et al. J Biol Chem, 2001 Jan 12. PMID 11027694
    4. Bacterial evolution through the selective loss of beneficial Genes. Trade-offs in expression involving two loci. Zinser ER, et al. Genetics, 2003 Aug. PMID 12930738, Free PMC Article
    5. A complexomic study of Escherichia coli using two-dimensional blue native/SDS polyacrylamide gel electrophoresis. Lasserre JP, et al. Electrophoresis, 2006 Aug. PMID 16858726

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the functional characterization of the Escherichia coli YbeK (RihA) protein as a pyrimidine nucleoside-preferring NH and its first crystal structure to 1.8 A resolution
      Title: New insights into the mechanism of nucleoside hydrolases from the crystal structure of the Escherichia coli YbeK protein bound to the reaction product.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables calcium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables purine nucleosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ribosylpyrimidine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ribosylpyrimidine nucleosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables uridine nucleosidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables uridine nucleosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables uridine nucleosidase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in nucleobase-containing compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nucleobase-containing small molecule interconversion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein homotetramerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleoside catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pyrimidine nucleobase metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within pyrimidine ribonucleoside catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyrimidine-specific ribonucleoside hydrolase RihA
    NP_415184.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      683477..684412 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_415184.1 pyrimidine-specific ribonucleoside hydrolase RihA [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_415184.1

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A5B9ANV0
      Conserved Domains (1) summary
      PRK10443
      Location:1 → 311
      rihA; ribonucleoside hydrolase 1; Provisional
    Nucleotide Protein
    Heading Accession and Version

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