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    xanQ xanthine:H(+) symporter XanQ [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 949075, updated on 17-Dec-2024

    Summary

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    Official Symbol
    xanQ
    Official Full Name
    xanthine:H(+) symporter XanQ
    Primary source
    ECOCYC:G7501
    Locus tag
    b2882
    See related
    ASAP:ABE-0009463
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK2878; ygfO
    Summary
    The YgfO protein is a member of the NCS2 family of nucleobase transporters. [More information is available at EcoCyc: G7501].
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    Genomic context

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    Sequence:
    NC_000913.3 (3024351..3025751)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene putative aminohydrolase SsnA Neighboring gene putative oxidoreductase Neighboring gene fused putative xanthine/hypoxanthine oxidase: molybdopterin-binding subunit and Fe-S binding subunit Neighboring gene guanine deaminase Neighboring gene guanine/hypoxanthine transporter GhxQ

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ. Karena E, et al. Mol Microbiol, 2015 Oct. PMID 26192456
    2. Role of intramembrane polar residues in the YgfO xanthine permease: HIS-31 and ASN-93 are crucial for affinity and specificity, and ASP-304 and GLU-272 are irreplaceable. Karena E, et al. J Biol Chem, 2009 Sep 4. PMID 19581302, Free PMC Article
    3. 2007 annual progress report synopsis of the Center for Structures of Membrane Proteins. Stroud RM, et al. J Struct Funct Genomics, 2009 Apr. PMID 19148774, Free PMC Article
    4. Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important. Papakostas K, et al. J Biol Chem, 2008 May 16. PMID 18359771
    5. Cysteine-scanning analysis of the nucleobase-ascorbate transporter signature motif in YgfO permease of Escherichia coli: Gln-324 and Asn-325 are essential, and Ile-329-Val-339 form an alpha-helix. Karatza P, et al. J Biol Chem, 2006 Dec 29. PMID 17077086

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Here, we present a comprehensive mutagenesis of XanQ based on the identification and Cys-scanning analysis of conserved sequence motifs in this cluster.
      Title: Analysis of conserved NCS2 motifs in the Escherichia coli xanthine permease XanQ.
    2. Ile-432 and Asn-430 of helix XII are crucial for purine uptake and affinity of YgfO, and Asn-430 is probably at the vicinity of the binding site
      Title: Cysteine-scanning analysis of putative helix XII in the YgfO xanthine permease: ILE-432 and ASN-430 are important.
    3. YgfO functions as specific, high-affinity transporter for xanthine, in a PMF-dependent manner. It does not recognize guanine, hypoxanthine, uracil or uric acid.
      Title: Cloning and functional characterization of two bacterial members of the NAT/NCS2 family in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables nucleobase transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables xanthine transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables xanthine transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in xanthine transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within xanthine transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    xanthine:H(+) symporter XanQ

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      3024351..3025751
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_417358.2 xanthine:H(+) symporter XanQ [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_417358.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8S7EH79
      Conserved Domains (1) summary
      TIGR00801
      Location:18 → 445
      ncs2; uracil-xanthine permease
    Nucleotide Protein
    Heading Accession and Version

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