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    zraP signaling pathway modulator ZraP [ Escherichia coli str. K-12 substr. MG1655 ]

    Gene ID: 948507, updated on 3-Dec-2024

    Summary

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    Official Symbol
    zraP
    Official Full Name
    signaling pathway modulator ZraP
    Primary source
    ECOCYC:EG11918
    Locus tag
    b4002
    See related
    ASAP:ABE-0013081
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Escherichia coli str. K-12 substr. MG1655 (strain: K-12, substrain: MG1655)
    Lineage
    Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales; Enterobacteriaceae; Escherichia
    Also known as
    ECK3994; yjaI; zra
    Summary
    ZraP is a periplasmic protein that is involved in zinc homeostasis . [More information is available at EcoCyc: EG11918].
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    Genomic context

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    Sequence:
    NC_000913.3 (4201263..4201688, complement)

    NC_000913.3Genomic Context describing neighboring genes Neighboring gene DNA-binding protein HU-alpha Neighboring gene DUF1481 domain-containing protein YjaH Neighboring gene sensor histidine kinase ZraS Neighboring gene DNA-binding transcriptional activator ZraR Neighboring gene phosphoribosylamine--glycine ligase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_000913.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ZraP, the most prominent zinc protein under zinc stress conditions has no direct role in in-vivo zinc tolerance in Escherichia coli. van der Weel L, et al. J Inorg Biochem, 2019 Mar. PMID 30616070
    2. A study on the dynamics of the zraP gene expression profile and its application to the construction of zinc adsorption bacteria. Ravikumar S, et al. Bioprocess Biosyst Eng, 2011 Nov. PMID 21674266
    3. A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra. Taher R, et al. Biochim Biophys Acta Gen Subj, 2021 Mar. PMID 33309686
    4. Biophysical and physiological characterization of ZraP from Escherichia coli, the periplasmic accessory protein of the atypical ZraSR two-component system. Petit-Härtlein I, et al. Biochem J, 2015 Dec 1. PMID 26438879
    5. The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli. Rome K, et al. J Mol Biol, 2018 Dec 7. PMID 30389436

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra.
      Title: A structure-function study of ZraP and ZraS provides new insights into the two-component system Zra.
    2. Deletion of the ZraP coding gene from the E. coli genome resulted in a phenotype with tolerance to very high zinc concentrations (up to 2.5mM) that were lethal to wild type E. coli. These results exclude a direct role for ZraP in Zn(2+) tolerance in E. coli.
      Title: ZraP, the most prominent zinc protein under zinc stress conditions has no direct role in in-vivo zinc tolerance in Escherichia coli.
    3. Study shows that the deletion of zraP or zraR confers increased susceptibility to five classes of antibiotics and to some environmental stress targeting the envelope. A microscopy approach establishes that ZraP and ZraR are required to maintain envelope integrity. ZraP protects the cell from envelope stress via its inhibitory function of the system.
      Title: The Two-Component System ZraPSR Is a Novel ESR that Contributes to Intrinsic Antibiotic Tolerance in Escherichia coli.
    4. zraP has a role in zinc adsorption and can be used for bioremediation
      Title: A study on the dynamics of the zraP gene expression profile and its application to the construction of zinc adsorption bacteria.
    5. N-terminus verified by Edman degradation on mature peptide
      Title: Identification of a novel transcription regulator from Proteus mirabilis, PMTR, revealed a possible role of YJAI protein in balancing zinc in Escherichia coli.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by EcoCyc

    Function Evidence Code Pubs
    enables cobalt ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nickel cation binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to cell envelope stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in outer membrane-bounded periplasmic space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in periplasmic space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    signaling pathway modulator ZraP

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_000913.3 Reference assembly

      Range
      4201263..4201688 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_418430.2 signaling pathway modulator ZraP [Escherichia coli str. K-12 substr. MG1655]

      See identical proteins and their annotated locations for NP_418430.2

      Status: PROVISIONAL

      UniProtKB/TrEMBL
      A0A8T6BIM6
      Conserved Domains (1) summary
      PRK11546
      Location:1 → 119
      zraP; zinc resistance sensor/chaperone ZraP
    Nucleotide Protein
    Heading Accession and Version

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