SAM4 S-adenosylmethionine-homocysteine S-methyltransferase SAM4 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: SAM4
Official Full Name: S-adenosylmethionine-homocysteine S-methyltransferase SAM4
Primary source: SGD:S000006194
Locus tag: YPL273W
See related: AllianceGenome:SGD:S000006194; FungiDB:YPL273W; VEuPathDB:YPL273W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables S-adenosylmethionine-homocysteine S-methyltransferase activity. Involved in L-methionine salvage from S-adenosylmethionine; S-adenosylhomocysteine metabolic process; and homocysteine metabolic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human BHMT2 (betaine--homocysteine S-methyltransferase 2). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

SAM4 and MHT1 have roles in recognition of age-damaged (R,S)-adenosyl-L-methionine
Title: Recognition of age-damaged (R,S)-adenosyl-L-methionine by two methyltransferases in the yeast Saccharomyces cerevisiae.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables S-adenosylmethionine-homocysteine S-methyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables S-adenosylmethionine-homocysteine S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables S-methylmethionine-homocysteine S-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in L-methionine salvage from S-adenosylmethionine	IDA Inferred from Direct Assay more info	PubMed
involved_in S-adenosylhomocysteine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in homocysteine metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in methionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in methylation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_015050.1

S-adenosylmethionine-homocysteine methyltransferase; functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio; SAM4 has a paralog, YMR321C, that arose from a single-locus duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain