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    dph-5 diphthine methyl ester synthase [ Caenorhabditis elegans ]

    Gene ID: 174737, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dph-5
    Official Full Name
    diphthine methyl ester synthase
    Primary source
    WormBase:WBGene00007194
    Locus tag
    CELE_B0491.7
    See related
    AllianceGenome:WB:WBGene00007194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable diphthine methyl ester synthase activity. Predicted to be involved in methylation and protein histidyl modification to diphthamide. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with short stature, prominent forehead, and feeding difficulties. Orthologous to human DPH5 (diphthamide biosynthesis 5). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See dph-5 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    3
    Sequence:
    Chromosome: II; NC_003280.10 (11350192..11351373)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA helicase Neighboring gene GPI mannosyltransferase 1 Neighboring gene Chloride channel protein Neighboring gene ncRNA Neighboring gene HEME_HALOPEROXIDASE domain-containing protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables diphthine methyl ester synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in methylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein histidyl modification to diphthamide IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    diphthine methyl ester synthase
    NP_496427.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11350192..11351373
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064026.2 → NP_496427.1  diphthine methyl ester synthase [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496427.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q17514
      Conserved Domains (1) summary
      PTZ00175
      Location:1 → 273
      PTZ00175; diphthine synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version

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