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    ERR2 phosphopyruvate hydratase ERR2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855848, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERR2
    Official Full Name
    phosphopyruvate hydratase ERR2
    Primary source
    SGD:S000006202
    Locus tag
    YPL281C
    See related
    AllianceGenome:SGD:S000006202; FungiDB:YPL281C; VEuPathDB:YPL281C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphopyruvate hydratase activity. Predicted to be involved in glycolytic process. Predicted to be part of phosphopyruvate hydratase complex. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human ENO1 (enolase 1) and ENO3 (enolase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERR2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (9557..10870, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Y' element ATP-dependent helicase protein 1 copy 7 Neighboring gene seripauperin PAU22 Neighboring gene glutathione-independent methylglyoxalase family protein Neighboring gene fluoride transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Sequence analysis of the right end of chromosome XV in Saccharomyces cerevisiae: an insight into the structural and functional significance of sub-telomeric repeat sequences. Pryde FE, et al. Yeast, 1995 Apr 15. PMID 7785338
    2. The Saccharomyces cerevisiae enolase-related regions encode proteins that are active enolases. Kornblatt MJ, et al. Yeast, 2013 Feb. PMID 23359425
    3. Autophagy as a Mechanism for Adaptive Prediction-Mediated Emergence of Drug Resistance. Nivedita N, et al. Front Microbiol, 2021. PMID 34566920, Free PMC Article
    4. The RasGAP proteins Ira2 and neurofibromin are negatively regulated by Gpb1 in yeast and ETEA in humans. Phan VT, et al. Mol Cell Biol, 2010 May. PMID 20160012, Free PMC Article
    5. Btn3 regulates the endosomal sorting function of the yeast Ent3 epsin, an adaptor for SNARE proteins. Morvan J, et al. J Cell Sci, 2015 Feb 15. PMID 25512335

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphopyruvate hydratase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphopyruvate hydratase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphopyruvate hydratase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables phosphopyruvate hydratase activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in glycolytic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolytic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    part_of phosphopyruvate hydratase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of phosphopyruvate hydratase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    phosphopyruvate hydratase ERR2
    NP_015042.1
    • Enolase, a phosphopyruvate hydratase; catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate; complements the growth defect of an ENO1 ENO2 double mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      9557..10870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184095.1 → NP_015042.1  TPA: phosphopyruvate hydratase ERR2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015042.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W385, P0CX10, P0CX11, Q12007, Q7LGJ4
      UniProtKB/TrEMBL
      A6ZVX7, B3LK45, B5VSR2, C7GSW8, C8ZHE0
      Conserved Domains (1) summary
      PTZ00081
      Location:1 → 428
      PTZ00081; enolase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX10.1
    P0CX11.1

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