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    SWD1 COMPASS subunit protein SWD1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851265, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SWD1
    Official Full Name
    COMPASS subunit protein SWD1
    Primary source
    SGD:S000000064
    Locus tag
    YAR003W
    See related
    AllianceGenome:SGD:S000000064; FungiDB:YAR003W; VEuPathDB:YAR003W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CPS50; FUN16; SAF49
    Summary
    Contributes to histone H3K4 methyltransferase activity. Involved in regulation of DNA-templated transcription; subtelomeric heterochromatin formation; and telomere maintenance. Part of Set1C/COMPASS complex. Orthologous to human RBBP5 (RB binding protein 5, histone lysine methyltransferase complex subunit). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SWD1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (155005..156285)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene FG-nucleoporin NUP60 Neighboring gene Erp1p Neighboring gene replication factor A subunit protein RFA1 Neighboring gene tRNA splicing endonuclease subunit SEN34

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Mitotically heritable, RNA polymerase II-independent H3K4 dimethylation stimulates INO1 transcriptional memory. Sump B, et al. Elife, 2022 May 17. PMID 35579426, Free PMC Article
    2. Tri-methylation of histone H3 lysine 4 facilitates gene expression in ageing cells. Cruz C, et al. Elife, 2018 Oct 2. PMID 30274593, Free PMC Article
    3. Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome. Worden EJ, et al. Elife, 2020 Jan 10. PMID 31922488, Free PMC Article
    4. Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae. Trainor BM, et al. G3 (Bethesda), 2021 Oct 19. PMID 34849786, Free PMC Article
    5. Histone Recycling by FACT and Spt6 during Transcription Prevents the Scrambling of Histone Modifications. Jeronimo C, et al. Cell Rep, 2019 Jul 30. PMID 31365865

    See all (109) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae.
      Title: Distinct requirements for the COMPASS core subunits Set1, Swd1, and Swd3 during meiosis in the budding yeast Saccharomyces cerevisiae.
    2. The affinity of the subunit Spp1 for modified histone H3 substrates is much higher than that of Swd1 and Swd3.
      Title: Characterising the binding specificities of the subunits associated with the KMT2/Set1 histone lysine methyltransferase.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to histone H3K4 methyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to histone H3K4 methyltransferase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in subtelomeric heterochromatin formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in telomere maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Set1C/COMPASS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set1C/COMPASS complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Set1C/COMPASS complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, telomeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    COMPASS subunit protein SWD1
    NP_009403.1
    • Subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      155005..156285
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178210.1 → NP_009403.1  TPA: COMPASS subunit protein SWD1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009403.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPL8, P39706
      UniProtKB/TrEMBL
      A7A0G9, B3LUT7, C7GTB4, C8Z3I0, G2W8N2, N1PAZ5
      Conserved Domains (2) summary
      sd00039
      Location:31 → 63
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:10 → 341
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39706.1

    Gene LinkOut

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