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    BTT1 CCR4-NOT core subunit BTT1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851839, updated on 9-Dec-2024

    Summary

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    Official Symbol
    BTT1
    Official Full Name
    CCR4-NOT core subunit BTT1
    Primary source
    SGD:S000002660
    Locus tag
    YDR252W
    See related
    AllianceGenome:SGD:S000002660; FungiDB:YDR252W; VEuPathDB:YDR252W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables unfolded protein binding activity. Involved in cotranslational protein targeting to membrane. Part of CCR4-NOT core complex and nascent polypeptide-associated complex. Orthologous to human BTF3 (basic transcription factor 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See BTT1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    1
    Sequence:
    Chromosome: IV; NC_001136.10 (963412..963861)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Pam1p Neighboring gene Met32p Neighboring gene Chl4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast BTF3 protein is encoded by duplicated genes and inhibits the expression of some genes in vivo. Hu GZ, et al. Nucleic Acids Res, 1994 Jul 25. PMID 8052529, Free PMC Article
    2. Initial characterization of the nascent polypeptide-associated complex in yeast. Reimann B, et al. Yeast, 1999 Mar 30. PMID 10219998
    3. The nascent polypeptide-associated complex (NAC) of yeast functions in the targeting process of ribosomes to the ER membrane. Wiedmann B, et al. FEBS Lett, 1999 Sep 10. PMID 10518932
    4. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast. Takahashi T, et al. J Toxicol Sci, 2009 Dec. PMID 19952507
    5. Functional Dissection of the Nascent Polypeptide-Associated Complex in Saccharomyces cerevisiae. Ott AK, et al. PLoS One, 2015. PMID 26618777, Free PMC Article

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
      Title: Dysfunctional nascent polypeptide-associated complex (NAC) activity in ribosomes enhances adriamycin toxicity in budding yeast.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables unfolded protein binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cotranslational protein targeting to membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of CCR4-NOT core complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nascent polypeptide-associated complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    CCR4-NOT core subunit BTT1
    NP_010538.1
    • Heterotrimeric nascent polypeptide-associated complex beta3 subunit; complex binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3; BTT1 has a paralog, EGD1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      963412..963861
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180560.1 → NP_010538.1  TPA: CCR4-NOT core subunit BTT1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010538.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZYK4, D6VSN2, P40314
      UniProtKB/TrEMBL
      B3LG38, C7GTI7, C8Z5G4, G2WAZ5, N1P6P4
      Conserved Domains (1) summary
      cd22055
      Location:9 → 125
      NAC_BTF3; basal transcription factor BTF3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40314.1

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