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    Mgat1 alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 81519, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mgat1provided by RGD
    Official Full Name
    alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferaseprovided by RGD
    Primary source
    RGD:620097
    See related
    EnsemblRapid:ENSRNOG00000068826 AllianceGenome:RGD:620097
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity and manganese ion binding activity. Predicted to be involved in protein N-linked glycosylation via asparagine. Predicted to act upstream of or within UDP-N-acetylglucosamine catabolic process and in utero embryonic development. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Orthologous to human MGAT1 (alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 298.6), Liver (RPKM 280.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mgat1 in Genome Data Viewer
    Location:
    10q21
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (34064548..34083833)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (33563642..33582718)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (34518392..34537214)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095085 Neighboring gene butyrophilin-like 9 Neighboring gene zinc finger protein 62 Neighboring gene uncharacterized LOC134480779 Neighboring gene olfactory receptor family 2 subfamily Y member 1G Neighboring gene olfactory receptor family 2 subfamily Y member 1H

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Genomic structure and 5'-flanking sequences of rat N-acetylglucosaminyltransferase I gene and regulatory role of its transcriptional diversity. Fukada T, et al. Biosci Biotechnol Biochem, 2003 Jul. PMID 12913295
    2. Are there two forms of beta 2-N-acetylglucosaminyltransferase I in rat testicular and epididymal fluids? Nozaki H, et al. Biochim Biophys Acta, 2003 Jul 30. PMID 12878032
    3. Different response to inflammation of the multiple mRNAs of rat N-acetylglucosaminyltransferase I with variable 5'-untranslated sequences. Fukada T, et al. FEBS Lett, 1998 Oct 2. PMID 9781684
    4. Cloning of a cDNA encoding N-acetylglucosaminyltransferase I from rat liver and analysis of its expression in rat tissues. Fukada T, et al. Biosci Biotechnol Biochem, 1994 Jan. PMID 7764514
    5. Mice lacking N-acetylglucosaminyltransferase I activity die at mid-gestation, revealing an essential role for complex or hybrid N-linked carbohydrates. Ioffe E, et al. Proc Natl Acad Sci U S A, 1994 Jan 18. PMID 8290590, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables manganese ion binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within UDP-N-acetylglucosamine catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation via asparagine ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein glycosylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase
    Names
    GNT-I
    MGAT1 gene for N-acetylglucosaminyltransferase
    N-acetylglucosaminyltransferase I
    N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I
    glcNAc-T I
    mannoside acetylglucosaminyltransferase 1
    mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
    NP_110488.1
    XP_006246244.1
    XP_006246245.1
    XP_006246246.1
    XP_006246247.1
    XP_063126006.1
    XP_063126007.1
    XP_063126008.1
    XP_063126009.1
    XP_063126010.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_030861.1 → NP_110488.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase

      See identical proteins and their annotated locations for NP_110488.1

      Status: PROVISIONAL

      Source sequence(s)
      D16302
      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1
      Related
      ENSRNOP00000083147.1, ENSRNOT00000100116.2
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      34064548..34083833
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269938.1 → XP_063126008.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1

    2. XM_063269940.1 → XP_063126010.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1

    3. XM_063269936.1 → XP_063126006.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1
      Related
      ENSRNOP00000110004.1, ENSRNOT00000168274.1

    4. XM_063269939.1 → XP_063126009.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1

    5. XM_006246184.5 → XP_006246246.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006246246.1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1
      Related
      ENSRNOP00000110059.1, ENSRNOT00000156181.1
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    6. XM_006246183.5 → XP_006246245.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006246245.1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1
      Related
      ENSRNOP00000090215.1, ENSRNOT00000106126.2
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    7. XM_006246185.4 → XP_006246247.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006246247.1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1
      Related
      ENSRNOP00000081858.1, ENSRNOT00000101283.2
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    8. XM_006246182.4 → XP_006246244.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      See identical proteins and their annotated locations for XP_006246244.1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1
      Conserved Domains (1) summary
      cl11394
      Location:12 → 446
      Glyco_tranf_GTA_type; Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold

    9. XM_063269937.1 → XP_063126007.1  alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase isoform X1

      UniProtKB/Swiss-Prot
      Q09325
      UniProtKB/TrEMBL
      A0A8L2R007, A6HDW1
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q09325.1 GenPept UniProtKB/Swiss-Prot:Q09325

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