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    Nucks1 nuclear casein kinase and cyclin-dependent kinase substrate 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64709, updated on 9-Dec-2024

    Summary

    Symbol
    Nucks1provided by RGD
    Full Name
    nuclear casein kinase and cyclin-dependent kinase substrate 1provided by RGD
    Primary source
    RGD:620993
    See related
    EnsemblRapid:ENSRNOG00000047287 AllianceGenome:RGD:620993
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Nucks
    Summary
    Enables single-stranded DNA binding activity. Predicted to be involved in several processes, including DNA metabolic process; cellular response to X-ray; and regulation of nucleobase-containing compound metabolic process. Predicted to act upstream of or within glucose homeostasis and positive regulation of insulin receptor signaling pathway. Predicted to be located in chromatin; nucleolus; and nucleoplasm. Predicted to be active in cytoplasm. Orthologous to human NUCKS1 (nuclear casein kinase and cyclin dependent kinase substrate 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 458.6), Brain (RPKM 444.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Nucks1 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (45897275..45926491)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (43345091..43374316)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (48679726..48709663)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene RAB29, member RAS oncogene family Neighboring gene uncharacterized LOC102556005 Neighboring gene RAN, member RAS oncogene family, pseudogene 4 Neighboring gene solute carrier family 45, member 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables double-stranded DNA binding NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables double-stranded DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded DNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
    Names
    cyclin-dependent kinase substrate
    nuclear ubiquitous casein and cyclin-dependent kinases substrate
    nuclear ubiquitous casein and cyclin-dependent kinases substrate-like
    nuclear ubiquitous casein kinase 2
    nuclear ubiquitous casein kinase and cyclin-dependent kinase substrate

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022799.2NP_073636.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

      See identical proteins and their annotated locations for NP_073636.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078818
      UniProtKB/Swiss-Prot
      Q9EPJ0
      UniProtKB/TrEMBL
      A0A8L2UNR4
      Related
      ENSRNOP00000065540.3, ENSRNOT00000075674.4

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      45897275..45926491
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249797.5XP_006249859.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X1

      UniProtKB/TrEMBL
      A0A8L2UNR4
    2. XM_063272581.1XP_063128651.1  nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform X2