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    Phactr4 phosphatase and actin regulator 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 682920, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Phactr4provided by RGD
    Official Full Name
    phosphatase and actin regulator 4provided by RGD
    Primary source
    RGD:1592823
    See related
    EnsemblRapid:ENSRNOG00000046922 AllianceGenome:RGD:1592823
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable actin binding activity; protein phosphatase 1 binding activity; and protein phosphatase activator activity. Predicted to be involved in several processes, including enteric nervous system development; morphogenesis of embryonic epithelium; and negative regulation of integrin-mediated signaling pathway. Predicted to be located in lamellipodium. Orthologous to human PHACTR4 (phosphatase and actin regulator 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 93.6), Lung (RPKM 67.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Phactr4 in Genome Data Viewer
    Location:
    5q36
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (149828716..149904955, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (144549350..144621259, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (150533895..150609423, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene tRNA selenocysteine 1 associated protein 1 Neighboring gene regulator of chromosome condensation 1 Neighboring gene small nucleolar RNA SNORA73 family Neighboring gene small nucleolar RNA, H/ACA box 73b Neighboring gene ferritin light chain 1-like Neighboring gene mediator complex subunit 18

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeting Phactr4 to rescue chronic stress-induced depression-like behavior in rats via regulating neuroinflammation and neuroplasticity. Li Y, et al. Int J Biol Macromol, 2024 Jul. PMID 38838879
    2. Phactr4 regulates directional migration of enteric neural crest through PP1, integrin signaling, and cofilin activity. Zhang Y, et al. Genes Dev, 2012 Jan 1. PMID 22215812, Free PMC Article
    3. Phactr4 regulates neural tube and optic fissure closure by controlling PP1-, Rb-, and E2F1-regulated cell-cycle progression. Kim TH, et al. Dev Cell, 2007 Jul. PMID 17609112
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Targeting Phactr4 to rescue chronic stress-induced depression-like behavior in rats via regulating neuroinflammation and neuroplasticity.
      Title: Targeting Phactr4 to rescue chronic stress-induced depression-like behavior in rats via regulating neuroinflammation and neuroplasticity.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase activator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Rho protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in closure of optic fissure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in enteric nervous system development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of integrin-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neural crest cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural tube closure ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of catalytic activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    phosphatase and actin regulator 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427181.1 → NP_001414110.1  phosphatase and actin regulator 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      M0R7T1

    2. NM_001427182.1 → NP_001414111.1  phosphatase and actin regulator 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6AQY6, M0R7T1
      Related
      ENSRNOP00000100258.1, ENSRNOT00000153713.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      149828716..149904955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063288416.1 → XP_063144486.1  phosphatase and actin regulator 4 isoform X9

      UniProtKB/TrEMBL
      A0A8I6AQY6, M0R7T1

    2. XM_063288413.1 → XP_063144483.1  phosphatase and actin regulator 4 isoform X6

      UniProtKB/TrEMBL
      M0R7T1

    3. XM_039111275.2 → XP_038967203.1  phosphatase and actin regulator 4 isoform X2

      UniProtKB/TrEMBL
      M0R7T1
      Conserved Domains (3) summary
      smart00707
      Location:620 → 644
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:172 → 554
      PHA03247; large tegument protein UL36; Provisional
      pfam02755
      Location:103 → 125
      RPEL; RPEL repeat

    4. XM_063288414.1 → XP_063144484.1  phosphatase and actin regulator 4 isoform X7

      UniProtKB/TrEMBL
      M0R7T1

    5. XM_063288411.1 → XP_063144481.1  phosphatase and actin regulator 4 isoform X4

      UniProtKB/TrEMBL
      A0A8I6AJP4, M0R7T1
      Related
      ENSRNOP00000093257.1, ENSRNOT00000111943.2

    6. XM_039111271.2 → XP_038967199.1  phosphatase and actin regulator 4 isoform X3

      Related
      ENSRNOP00000095468.2, ENSRNOT00000107632.2
      Conserved Domains (2) summary
      smart00707
      Location:607 → 631
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:159 → 541
      PHA03247; large tegument protein UL36; Provisional

    7. XM_039111276.2 → XP_038967204.1  phosphatase and actin regulator 4 isoform X1

      Conserved Domains (3) summary
      smart00707
      Location:634 → 658
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:186 → 568
      PHA03247; large tegument protein UL36; Provisional
      pfam02755
      Location:117 → 139
      RPEL; RPEL repeat

    8. XM_039111273.2 → XP_038967201.1  phosphatase and actin regulator 4 isoform X5

      UniProtKB/TrEMBL
      A0A8I6AZ06, M0R7T1
      Related
      ENSRNOP00000094116.1, ENSRNOT00000105203.2
      Conserved Domains (3) summary
      smart00707
      Location:592 → 616
      RPEL; Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2
      PHA03247
      Location:144 → 526
      PHA03247; large tegument protein UL36; Provisional
      pfam02755
      Location:75 → 97
      RPEL; RPEL repeat

    9. XM_063288415.1 → XP_063144485.1  phosphatase and actin regulator 4 isoform X8

      UniProtKB/TrEMBL
      M0R7T1
    Nucleotide Protein Strain
    Heading Accession and Version

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