Krt12 keratin 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Krt12provided by RGD
Official Full Name: keratin 12provided by RGD
Primary source: RGD:1304805
See related: EnsemblRapid:ENSRNOG00000011986 AllianceGenome:RGD:1304805
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ka12; Krt1-12
Summary: Predicted to enable structural molecule activity. Predicted to be involved in several processes, including cornea development in camera-type eye; epithelial cell differentiation; and intermediate filament organization. Predicted to act upstream of or within epithelium development. Predicted to be located in intermediate filament. Predicted to be active in cytoskeleton. Human ortholog(s) of this gene implicated in Meesmann corneal dystrophy 1 and corneal dystrophy. Orthologous to human KRT12 (keratin 12). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 5.0), Muscle (RPKM 2.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (84866965..84874265, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (84370803..84378103, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (87328547..87336710, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BG372502 (e-PCR)
- UniSTS:248924

AI835216 (e-PCR)
- UniSTS:165797

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in cornea development in camera-type eye	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in cornea development in camera-type eye	ISO Inferred from Sequence Orthology more info
involved_in cornea development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within epithelium development	ISO Inferred from Sequence Orthology more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in morphogenesis of an epithelium	IBA Inferred from Biological aspect of Ancestor more info
involved_in morphogenesis of an epithelium	IEA Inferred from Electronic Annotation more info
involved_in morphogenesis of an epithelium	ISO Inferred from Sequence Orthology more info
involved_in morphogenesis of an epithelium	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 12

Names: CK-12; K12; cytokeratin-12; keratin 12 (Meesmann corneal dystrophy); keratin 12, type I; keratin K12; keratin complex 1, acidic, gene 12; type I keratin KA12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001395659.1 → NP_001382588.1 keratin, type I cytoskeletal 12

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

Q6IFW5

UniProtKB/TrEMBL

A0A0G2K4H9

Related

ENSRNOP00000073050.1, ENSRNOT00000079297.3

Conserved Domains (1) summary

pfam00038
Location:114 → 424

Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

84866965..84874265 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269430.1 → XP_063125500.1 keratin, type I cytoskeletal 12 isoform X1

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001008761.1: Suppressed sequence

Description

NM_001008761.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.