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    Rapgef5 Rap guanine nucleotide exchange factor 5 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362799, updated on 27-Nov-2024

    Summary

    Official Symbol
    Rapgef5provided by RGD
    Official Full Name
    Rap guanine nucleotide exchange factor 5provided by RGD
    Primary source
    RGD:1561668
    See related
    EnsemblRapid:ENSRNOG00000005271 AllianceGenome:RGD:1561668
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mrgef; rMR-GEF; RGD1562891
    Summary
    Predicted to enable GTP-dependent protein binding activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in Ras protein signal transduction. Predicted to be located in nuclear body. Predicted to be active in plasma membrane. Orthologous to human RAPGEF5 (Rap guanine nucleotide exchange factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Lung (RPKM 182.1), Brain (RPKM 177.8) and 9 other tissues See more
    Orthologs
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    Genomic context

    See Rapgef5 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (144588162..144822908)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (138445184..138679943)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (145387890..145625243)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene lactate dehydrogenase A, pseudogene 25 Neighboring gene uncharacterized LOC120093171 Neighboring gene uncharacterized LOC102556588 Neighboring gene uncharacterized LOC134479493 Neighboring gene 60S acidic ribosomal protein P2 pseudogene Neighboring gene cell division cycle associated 7 like Neighboring gene ribosomal protein L32, pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables GTP-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in small GTPase-mediated signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    rap guanine nucleotide exchange factor 5
    Names
    M-Ras-regulated Rap GEF
    MR-GEF
    Rap guanine nucleotide exchange factor (GEF) 5
    guanine nucleotide exchange factor for Rap1-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001047915.2NP_001041380.2  rap guanine nucleotide exchange factor 5 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/Swiss-Prot
      P83900
      Related
      ENSRNOP00000087207.1, ENSRNOT00000117361.2
      Conserved Domains (2) summary
      smart00147
      Location:340579
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:67199
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    2. NM_001395143.1NP_001382072.1  rap guanine nucleotide exchange factor 5 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A0A8I6A853, F1M888
      Related
      ENSRNOP00000087882.1, ENSRNOT00000099532.2
      Conserved Domains (3) summary
      smart00147
      Location:640879
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases
      smart00229
      Location:368499
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd04437
      Location:98221
      DEP_Epac; DEP (Dishevelled, Egl-10, and Pleckstrin) domain found in Epac-like proteins. Epac (exchange proteins directly activated by cAMP) proteins are GEFs (guanine-nucleotide-exchange factors) for the small GTPases, Rap1 and Rap2. They are directly regulated by ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      144588162..144822908
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)