Pxdn peroxidasin [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pxdnprovided by RGD
Official Full Name: peroxidasinprovided by RGD
Primary source: RGD:1560694
See related: EnsemblRapid:ENSRNOG00000060614 AllianceGenome:RGD:1560694
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Vpo1; Perc64
Summary: Predicted to enable heme binding activity; laminin-1 binding activity; and peroxidase activity. Predicted to be an extracellular matrix structural constituent. Predicted to be involved in several processes, including extracellular matrix organization; hydrogen peroxide catabolic process; and protein homotrimerization. Predicted to be located in several cellular components, including basement membrane; cell surface; and endoplasmic reticulum. Human ortholog(s) of this gene implicated in anterior segment dysgenesis 7. Orthologous to human PXDN (peroxidasin). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Lung (RPKM 521.8), Heart (RPKM 325.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (52308347..52385943)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (46580749..46658345)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (48866496..48982368)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Vascular peroxidase 1 promotes phenotypic transformation of pulmonary artery smooth muscle cells via ERK pathway in hypoxia-induced pulmonary hypertensive rats.
Title: Vascular peroxidase 1 promotes phenotypic transformation of pulmonary artery smooth muscle cells via ERK pathway in hypoxia-induced pulmonary hypertensive rats.
NOX/VPO1 pathway-derived reactive oxygen species promote the oxidative injury and dysfunctions of EPCs in PH, which may contribute to endothelial dysfunctions in PH
Title: Coordination between NADPH oxidase and vascular peroxidase 1 promotes dysfunctions of endothelial progenitor cells in hypoxia-induced pulmonary hypertensive rats.
VPO1 promotes hypoxia-induced proliferation, apoptosis resistance, and migration in pulmonary artery smooth muscle cells via the NOX4/VPO1/HOCl/NF-kappaB signalling pathway.
Title: Vascular peroxidase 1 mediates hypoxia-induced pulmonary artery smooth muscle cell proliferation, apoptosis resistance and migration.
VPO1 promotes cardiac remodeling by accelerating the Ang II-induced hypertrophy of H9c2 cell via the NOX2/VPO1/HOCl/ERK1/2 signaling pathways.
Title: Involvement of vascular peroxidase 1 in angiotensin II-induced hypertrophy of H9c2 cells.
The over-expression of VPO1 during the development of hypertension, accompanied by the endothelial dysfunction, the decreased NO levels, the elevated NOX and ROS activities, indicates a clear connection between VPO1 gene and hypertension.(VPO1)
Title: Vascular VPO1 expression is related to the endothelial dysfunction in spontaneously hypertensive rats.
Vascular peroxidase 1/peroxidasin is a novel regulator of angiotensin II-induced vascular smooth muscle cell proliferation via NADPH oxidase-hydrogen peroxide pathways.
Title: Involvement of vascular peroxidase 1 in angiotensin II-induced vascular smooth muscle cell proliferation.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables extracellular matrix structural constituent	ISO Inferred from Sequence Orthology more info
enables heme binding	ISO Inferred from Sequence Orthology more info
enables lactoperoxidase activity	IEA Inferred from Electronic Annotation more info
enables laminin-1 binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on peroxide as acceptor	ISO Inferred from Sequence Orthology more info
enables peroxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peroxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of basement membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in basement membrane assembly	ISO Inferred from Sequence Orthology more info
involved_in basement membrane organization	ISO Inferred from Sequence Orthology more info
involved_in cell adhesion	ISO Inferred from Sequence Orthology more info
involved_in cellular oxidant detoxification	IEA Inferred from Electronic Annotation more info
involved_in collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in eye development	ISO Inferred from Sequence Orthology more info
involved_in hydrogen peroxide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in protein homooligomerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in response to oxidative stress	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peroxidasin homolog

Names: PE responsive protein c64; melanoma-associated antigen MG50

NP_001258190.1

EC 1.11.1.7

XP_038968721.1

EC 1.11.1.7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271261.1 → NP_001258190.1 peroxidasin homolog precursor

Status: VALIDATED

Source sequence(s)

FQ140997, JAXUCZ010000006

UniProtKB/TrEMBL

A0A0G2JWB6, A6HB27

Related

ENSRNOP00000069815.2, ENSRNOT00000079891.3

Conserved Domains (12) summary

cd05745
Location:443 → 516

Ig3_Peroxidasin; Third immunoglobulin (Ig)-like domain of peroxidasin

cd05746
Location:539 → 607

Ig4_Peroxidasin; Fourth immunoglobulin (Ig)-like domain of peroxidasin

cd09826
Location:861 → 1300

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

smart00214
Location:1411 → 1466

VWC; von Willebrand factor (vWF) type C domain

pfam07679
Location:430 → 516

I-set; Immunoglobulin I-set domain

sd00031
Location:109 → 132

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:63 → 84

LRR_RI; leucine-rich repeat [structural motif]

pfam03098
Location:738 → 1279

An_peroxidase; Animal haem peroxidase

pfam12799
Location:107 → 148

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:108 → 167

LRR_8; Leucine rich repeat

cl11960
Location:243 → 330

Ig; Immunoglobulin domain

cl15307
Location:189 → 240

TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

52308347..52385943

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039112793.2 → XP_038968721.1 peroxidasin homolog isoform X1

UniProtKB/TrEMBL

A0A0G2KAH2, A6HB27

Related

ENSRNOP00000075396.2, ENSRNOT00000077321.3

Conserved Domains (10) summary

cd05745
Location:419 → 492

Ig3_Peroxidasin; Third immunoglobulin (Ig)-like domain of peroxidasin

cd05746
Location:515 → 583

Ig4_Peroxidasin; Fourth immunoglobulin (Ig)-like domain of peroxidasin

cd09826
Location:837 → 1276

peroxidasin_like; Animal heme peroxidase domain of peroxidasin and related proteins

smart00214
Location:1387 → 1442

VWC; von Willebrand factor (vWF) type C domain

COG4886
Location:51 → 215

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00031
Location:61 → 75

LRR_1; leucine-rich repeat [structural motif]

sd00033
Location:42 → 60

LRR_RI; leucine-rich repeat [structural motif]

pfam07679
Location:315 → 402

I-set; Immunoglobulin I-set domain

pfam13855
Location:108 → 167

LRR_8; Leucine rich repeat

cd00096
Location:323 → 326

Ig; Ig strand A' [structural motif]