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    Ncapg2 non-SMC condensin II complex, subunit G2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362798, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Ncapg2provided by RGD
    Official Full Name
    non-SMC condensin II complex, subunit G2provided by RGD
    Primary source
    RGD:1308406
    See related
    EnsemblRapid:ENSRNOG00000004968 AllianceGenome:RGD:1308406
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Luzp5; RGD1308406
    Summary
    Predicted to enable bHLH transcription factor binding activity and methylated histone binding activity. Predicted to be involved in mitotic sister chromatid segregation; positive regulation of chromosome segregation; and positive regulation of chromosome separation. Predicted to act upstream of with a positive effect on erythrocyte differentiation. Predicted to act upstream of with a negative effect on transcription by RNA polymerase II. Predicted to act upstream of or within inner cell mass cell proliferation. Predicted to be located in condensed nuclear chromosome and nuclear speck. Predicted to be part of condensin complex. Predicted to be active in nucleus. Orthologous to human NCAPG2 (non-SMC condensin II complex subunit G2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 134.2), Spleen (RPKM 94.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ncapg2 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    31
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143484651..143561850)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (137342449..137418083)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (144291313..144362454)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L32, pseudogene 17 Neighboring gene uncharacterized LOC134479490 Neighboring gene extended synaptotagmin 2 Neighboring gene uncharacterized LOC102548847 Neighboring gene uncharacterized LOC120093226 Neighboring gene protein tyrosine phosphatase, receptor type N2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. More than blood, a novel gene required for mammalian postimplantation development. Smith ED, et al. Mol Cell Biol, 2004 Feb. PMID 14729962, Free PMC Article
    2. MTB, the murine homolog of condensin II subunit CAP-G2, represses transcription and promotes erythroid cell differentiation. Xu Y, et al. Leukemia, 2006 Jul. PMID 16673016
    3. PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression. Liu W, et al. Nature, 2010 Jul 22. PMID 20622854, Free PMC Article
    4. Condensins I and II are essential for construction of bivalent chromosomes in mouse oocytes. Lee J, et al. Mol Biol Cell, 2011 Sep. PMID 21795393, Free PMC Article
    5. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables bHLH transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_positive_effect erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within inner cell mass cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mitotic sister chromatid segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of chromosome separation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_negative_effect transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of condensin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of condensin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    condensin-2 complex subunit G2
    Names
    leucine zipper protein 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427667.1 → NP_001414596.1  condensin-2 complex subunit G2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      Related
      ENSRNOP00000107065.1, ENSRNOT00000141893.1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      143484651..143561850
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063262159.1 → XP_063118229.1  condensin-2 complex subunit G2 isoform X4

    2. XM_063262158.1 → XP_063118228.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2

    3. XM_063262156.1 → XP_063118226.1  condensin-2 complex subunit G2 isoform X1

    4. XM_063262157.1 → XP_063118227.1  condensin-2 complex subunit G2 isoform X2

    5. XM_039078085.2 → XP_038934013.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2
      Conserved Domains (3) summary
      COG5096
      Location:338 → 483
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    6. XM_039078086.2 → XP_038934014.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2
      Related
      ENSRNOP00000106240.1, ENSRNOT00000157778.1
      Conserved Domains (3) summary
      COG5096
      Location:338 → 483
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    7. XM_039078084.2 → XP_038934012.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2
      Conserved Domains (3) summary
      COG5096
      Location:338 → 483
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    8. XM_063262160.1 → XP_063118230.1  condensin-2 complex subunit G2 isoform X5

    9. XM_039078080.2 → XP_038934008.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2
      Conserved Domains (3) summary
      COG5096
      Location:338 → 483
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    10. XM_343124.10 → XP_343125.5  condensin-2 complex subunit G2 isoform X5

      See identical proteins and their annotated locations for XP_343125.5

      UniProtKB/TrEMBL
      D4AAL2
      Conserved Domains (2) summary
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]

    11. XM_039078083.2 → XP_038934011.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2
      Conserved Domains (3) summary
      COG5096
      Location:338 → 483
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    12. XM_063262161.1 → XP_063118231.1  condensin-2 complex subunit G2 isoform X5

    13. XM_063262162.1 → XP_063118232.1  condensin-2 complex subunit G2 isoform X5

    14. XM_039078081.2 → XP_038934009.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2
      Conserved Domains (3) summary
      COG5096
      Location:338 → 483
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    15. XM_039078089.2 → XP_038934017.1  condensin-2 complex subunit G2 isoform X6

      Conserved Domains (3) summary
      COG5096
      Location:258 → 403
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:296 → 324
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:132 → 280
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    16. XM_039078087.2 → XP_038934015.1  condensin-2 complex subunit G2 isoform X3

      UniProtKB/TrEMBL
      D4AAL2
      Conserved Domains (3) summary
      COG5096
      Location:338 → 483
      COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]
      sd00044
      Location:376 → 404
      HEAT; HEAT repeat [structural motif]
      pfam12422
      Location:212 → 360
      Condensin2nSMC; Condensin II non structural maintenance of chromosomes subunit

    RNA

    1. XR_010052125.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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