Rptor regulatory associated protein of MTOR, complex 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rptorprovided by RGD
Official Full Name: regulatory associated protein of MTOR, complex 1provided by RGD
Primary source: RGD:1311784
See related: EnsemblRapid:ENSRNOG00000003821 AllianceGenome:RGD:1311784
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1311784
Summary: Enables protein kinase binding activity. Involved in positive regulation of endothelial cell proliferation and regulation of phosphorylation. Located in dendrite and neuronal cell body. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 71.6), Kidney (RPKM 67.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (105376943..105675416)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (104878487..105176986)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (108750620..109058691)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Up-regulation of mTORC1 via raptor by aldosterone is a critical pathobiologic mechanism that controls pulmonary artery smooth muscle cell survival to promote hypertrophic vascular remodeling and pulmonary arterial hypertension.
Title: Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension.
These results disclosed that, under endoplasmic reticulum stress conditions, mTORC1 causes apoptosis through suppression of Akt and consequent induction of the IRE1-JNK pathway.
Title: mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway.
a previously unrecognized function of miR-21 that is the reciprocal regulation of PTEN levels and Akt/TORC1 activity that mediate critical pathologic features of diabetic kidney disease
Title: MicroRNA-21 orchestrates high glucose-induced signals to TOR complex 1, resulting in renal cell pathology in diabetes.

Submit: New GeneRIF Correction

General gene information

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Markers

D10Rat108 (e-PCR), detects polymorphism
- UniSTS:226271

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	ISO Inferred from Sequence Orthology more info
enables enzyme-substrate adaptor activity	ISO Inferred from Sequence Orthology more info
enables protein kinase activator activity	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein serine/threonine kinase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables protein-macromolecule adaptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein-macromolecule adaptor activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in TORC1 signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in TORC1 signaling	ISO Inferred from Sequence Orthology more info
involved_in cellular response to L-leucine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to nutrient levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to starvation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of insulin secretion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of G1/S transition of mitotic cell cycle	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of TOR signaling	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell growth	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of odontoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of osteoclast differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-serine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of peptidyl-threonine phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase III	ISO Inferred from Sequence Orthology more info
involved_in regulation of autophagy	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell size	ISO Inferred from Sequence Orthology more info
involved_in regulation of phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in response to xenobiotic stimulus	ISO Inferred from Sequence Orthology more info
involved_in social behavior	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of TORC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TORC1 complex	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic stress granule	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
is_active_in lysosomal membrane	ISO Inferred from Sequence Orthology more info
located_in lysosome	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: regulatory-associated protein of mTOR

Names: raptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001134499.2 → NP_001127971.2 regulatory-associated protein of mTOR

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6HL94, D3ZDU2

Related

ENSRNOP00000005337.6, ENSRNOT00000005337.8

Conserved Domains (6) summary

COG5096
Location:472 → 696

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

sd00044
Location:516 → 544

HEAT; HEAT repeat [structural motif]

sd00039
Location:1027 → 1063

7WD40; WD40 repeat [structural motif]

pfam13646
Location:566 → 668

HEAT_2; HEAT repeats

pfam14538
Location:55 → 206

Raptor_N; Raptor N-terminal CASPase like domain

cl29593
Location:1027 → 1322

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

105376943..105675416

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039085689.2 → XP_038941617.1 regulatory-associated protein of mTOR isoform X1

UniProtKB/TrEMBL

A0A8I6ANV2, A6HL94

Related

ENSRNOP00000098000.1, ENSRNOT00000101121.2

Conserved Domains (6) summary

COG5096
Location:423 → 647

COG5096; Vesicle coat complex, various subunits [Intracellular trafficking, secretion, and vesicular transport]

sd00044
Location:467 → 495

HEAT; HEAT repeat [structural motif]

sd00039
Location:978 → 1014

7WD40; WD40 repeat [structural motif]

pfam13646
Location:517 → 619

HEAT_2; HEAT repeats

pfam14538
Location:55 → 169

Raptor_N; Raptor N-terminal CASPase like domain

cl29593
Location:978 → 1273

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...