U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Esyt2 extended synaptotagmin 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 299488, updated on 27-Nov-2024

    Summary

    Symbol
    Esyt2provided by RGD
    Full Name
    extended synaptotagmin 2provided by RGD
    Primary source
    RGD:1565705
    See related
    EnsemblRapid:ENSRNOG00000032391 AllianceGenome:RGD:1565705
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1565705
    Summary
    Predicted to enable calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in cytoplasmic side of plasma membrane; cytosol; and endoplasmic reticulum-plasma membrane contact site. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Thymus (RPKM 388.5), Lung (RPKM 273.1) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Esyt2 in Genome Data Viewer
    Location:
    6q33
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (143359870..143455600)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (137219653..137312590)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (144156021..144248374)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134479489 Neighboring gene dynein 2 intermediate chain 1 Neighboring gene ribosomal protein L32, pseudogene 17 Neighboring gene uncharacterized LOC134479490 Neighboring gene non-SMC condensin II complex, subunit G2 Neighboring gene uncharacterized LOC102548847

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipid binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylcholine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylcholine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylethanolamine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylethanolamine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in endoplasmic reticulum-plasma membrane tethering IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum-plasma membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in organelle membrane contact site ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    extended synaptotagmin-2
    Names
    extended synaptotagmin protein 2
    extended synaptotagmin-like protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001271169.1NP_001258098.1  extended synaptotagmin-2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006
      UniProtKB/TrEMBL
      A6KDL4, D3ZJ32
      Related
      ENSRNOP00000006582.7, ENSRNOT00000006582.9
      Conserved Domains (4) summary
      cd04030
      Location:710835
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461566
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      143359870..143455600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261796.1XP_063117866.1  extended synaptotagmin-2 isoform X1

    2. XM_039112112.2XP_038968040.1  extended synaptotagmin-2 isoform X4

      Related
      ENSRNOP00000099023.1, ENSRNOT00000145580.1
      Conserved Domains (4) summary
      cd04030
      Location:765890
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461621
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    3. XM_063261797.1XP_063117867.1  extended synaptotagmin-2 isoform X2

    4. XM_039112113.2XP_038968041.1  extended synaptotagmin-2 isoform X6

      Related
      ENSRNOP00000109126.1, ENSRNOT00000139772.1
      Conserved Domains (4) summary
      cd04030
      Location:744869
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461600
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    5. XM_063261798.1XP_063117868.1  extended synaptotagmin-2 isoform X3

    6. XM_039112114.2XP_038968042.1  extended synaptotagmin-2 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A660
      Related
      ENSRNOP00000086527.1, ENSRNOT00000117706.2
      Conserved Domains (4) summary
      cd04030
      Location:731856
      C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins
      cd04050
      Location:461587
      C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    7. XM_063261799.1XP_063117869.1  extended synaptotagmin-2 isoform X5

    8. XM_039112119.2XP_038968047.1  extended synaptotagmin-2 isoform X10

      Conserved Domains (2) summary
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    9. XM_039112120.2XP_038968048.1  extended synaptotagmin-2 isoform X11

      Conserved Domains (2) summary
      cd08391
      Location:309429
      C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins
      pfam17047
      Location:115294
      SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
    10. XM_063261800.1XP_063117870.1  extended synaptotagmin-2 isoform X8

    11. XM_063261801.1XP_063117871.1  extended synaptotagmin-2 isoform X9