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    Plekhh2 pleckstrin homology, MyTH4 and FERM domain containing H2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313866, updated on 27-Nov-2024

    Summary

    Official Symbol
    Plekhh2provided by RGD
    Official Full Name
    pleckstrin homology, MyTH4 and FERM domain containing H2provided by RGD
    Primary source
    RGD:1304935
    See related
    EnsemblRapid:ENSRNOG00000005124 AllianceGenome:RGD:1304935
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304935
    Summary
    Predicted to enable actin binding activity. Predicted to be involved in negative regulation of actin filament depolymerization. Predicted to be located in several cellular components, including cortical actin cytoskeleton; lamellipodium; and nuclear body. Predicted to be active in cytoplasm. Orthologous to human PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 97.0), Uterus (RPKM 70.7) and 9 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Plekhh2 in Genome Data Viewer
    Location:
    6q12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (15783179..15893479, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (10032837..10132081, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (7784743..7895986)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene dynein cytoplasmic 2 light intermediate chain 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC134479315 Neighboring gene uncharacterized LOC134479314 Neighboring gene THADA, armadillo repeat containing Neighboring gene zinc finger protein 36, C3H type-like 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of actin filament depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of actin filament depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cortical actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    pleckstrin homology domain-containing family H member 2
    Names
    pleckstrin homology domain containing, family H (with MyTH4 domain) member 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191770.3NP_001178699.3  pleckstrin homology domain-containing family H member 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      15783179..15893479 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261831.1XP_063117901.1  pleckstrin homology domain-containing family H member 2 isoform X1

      Related
      ENSRNOP00000006832.6, ENSRNOT00000006832.6
    2. XM_063261832.1XP_063117902.1  pleckstrin homology domain-containing family H member 2 isoform X2

    3. XM_063261838.1XP_063117908.1  pleckstrin homology domain-containing family H member 2 isoform X7

    4. XM_063261835.1XP_063117905.1  pleckstrin homology domain-containing family H member 2 isoform X5

    5. XM_063261830.1XP_063117900.1  pleckstrin homology domain-containing family H member 2 isoform X1

    6. XM_063261840.1XP_063117910.1  pleckstrin homology domain-containing family H member 2 isoform X9

    7. XM_063261841.1XP_063117911.1  pleckstrin homology domain-containing family H member 2 isoform X10

    8. XM_063261846.1XP_063117916.1  pleckstrin homology domain-containing family H member 2 isoform X13

    9. XM_063261839.1XP_063117909.1  pleckstrin homology domain-containing family H member 2 isoform X8

    10. XM_063261836.1XP_063117906.1  pleckstrin homology domain-containing family H member 2 isoform X6

    11. XM_063261843.1XP_063117913.1  pleckstrin homology domain-containing family H member 2 isoform X12

    12. XM_063261844.1XP_063117914.1  pleckstrin homology domain-containing family H member 2 isoform X12

    13. XM_063261837.1XP_063117907.1  pleckstrin homology domain-containing family H member 2 isoform X6

    14. XM_063261833.1XP_063117903.1  pleckstrin homology domain-containing family H member 2 isoform X3

    15. XM_063261834.1XP_063117904.1  pleckstrin homology domain-containing family H member 2 isoform X4

    16. XM_063261847.1XP_063117917.1  pleckstrin homology domain-containing family H member 2 isoform X14

    17. XM_063261849.1XP_063117919.1  pleckstrin homology domain-containing family H member 2 isoform X16

    18. XM_063261848.1XP_063117918.1  pleckstrin homology domain-containing family H member 2 isoform X15

    19. XM_063261842.1XP_063117912.1  pleckstrin homology domain-containing family H member 2 isoform X11

    RNA

    1. XR_010052082.1 RNA Sequence